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10.1016/j.imlet.2018.10.010 http://scihub22266oqcxt.onion/10.1016/j.imlet.2018.10.010 30447311!ä!30447311 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunol+Lett 2018 ; 201 (ä): 20-30 Nephropedia Template TP {{tp|p=30447311|t=2018. Impact of the GK-1 adjuvant on peritoneal macrophages gene expression and phagocytosis |pdf=|usr=}}{{30447311}} gab.com Text Impact of the GK-1 adjuvant on peritoneal macrophages gene expression and phagocytosis JO: Immunol Lett http://www.kidney.de/pget.php?&tw=1&pmid=30447311 #FOAvip PURPOSE: The synthetic peptide GK-1 potentiates protective immunity elicited by the influenza vaccine in mice. In order to understand its adjuvant properties, this study was designed to determine the impact of GK-1 on gene expression and phagocytosis of peritoneal macrophages (PMa). METHODS: Increased gene expression of chemokines involved in leukocyte recruitment and of pro-inflammatory mediators was detected by microarray analysis of control and GK-1 treated PMa macrophages. The expression profile was subsequently confirmed by Multiplex Immunoassays analysis to measure cytokines levels, flow cytometer to describe M1/M2 surface markers and an assay to evaluate their phagocytic activity. RESULTS: Treatment of PMa with GK-1 results in development to the classically activated M1 functional macrophage subpopulation with increased expression of the CCL3 and CXCLO2 chemokines, IL-6 and TNF-alpha proinflammatory cytokines with a concomitant increase in the levels of NO, accompanied by the expression of modulatory factors that downregulate the inflammatory phenotype. GK-1 treated PMa significantly increased their phagocytic activity. CONCLUSION: GK-1 classical activated with enhanced phagocitic capacity may underlie in the increased specific immunity induced when concomitant administered with other antigens. Twit Text FOAVip Impact of the GK-1 adjuvant on peritoneal macrophages gene expression and phagocytosis ????Immunol Lett http://www.kidney.de/pget.php?&tw=1&pmid=30447311 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30447311 #FOAvip English Wikipedia <ref>{{Cite pmid|30447311}}</ref> Impact of the GK-1 adjuvant on peritoneal macrophages gene expression and phagocytosis #MMPMID30447311 Sanchez-Hernandez L; Montero L; Mojica-Espinosa R; Reyes-Grajeda JP; Cervantes-Torres J; Parkhouse RM; Fragoso G; Sciutto E Immunol Lett 2018[Sep]; 201 (ä): 20-30 PMID30447311show ga PURPOSE: The synthetic peptide GK-1 potentiates protective immunity elicited by the influenza vaccine in mice. In order to understand its adjuvant properties, this study was designed to determine the impact of GK-1 on gene expression and phagocytosis of peritoneal macrophages (PMa). METHODS: Increased gene expression of chemokines involved in leukocyte recruitment and of pro-inflammatory mediators was detected by microarray analysis of control and GK-1 treated PMa macrophages. The expression profile was subsequently confirmed by Multiplex Immunoassays analysis to measure cytokines levels, flow cytometer to describe M1/M2 surface markers and an assay to evaluate their phagocytic activity. RESULTS: Treatment of PMa with GK-1 results in development to the classically activated M1 functional macrophage subpopulation with increased expression of the CCL3 and CXCLO2 chemokines, IL-6 and TNF-alpha proinflammatory cytokines with a concomitant increase in the levels of NO, accompanied by the expression of modulatory factors that downregulate the inflammatory phenotype. GK-1 treated PMa significantly increased their phagocytic activity. CONCLUSION: GK-1 classical activated with enhanced phagocitic capacity may underlie in the increased specific immunity induced when concomitant administered with other antigens. |Adjuvants, Immunologic/*metabolism[MESH] |Animals[MESH] |Cells, Cultured[MESH] |Chemokine CCL3/genetics[MESH] |Female[MESH] |Gene Expression Regulation[MESH] |Immunity, Innate[MESH] |Immunization[MESH] |Interleukin-6/genetics[MESH] |Macrophages, Peritoneal/*metabolism[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Peptides, Cyclic/*metabolism[MESH] |Phagocytosis[MESH]Impact of the GK-1 adjuvant on peritoneal macrophages gene expression (epmc).pdf DeepDyve Pubget Overpricing