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10.1109/EMBC.2018.8513572 http://scihub22266oqcxt.onion/10.1109/EMBC.2018.8513572 30441573!?!30441573 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30441573&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Annu+Int+Conf+IEEE+Eng+Med+Biol+Soc 2018 ; 2018 (?): 5462-5465 Nephropedia Template TP {{tp|p=30441573|t=2018. Computational Analysis of the Action of Chloroquine on Short QT Syndrome Variant 1 and Variant 3 in Human Ventricles |pdf=|usr=}}{{30441573}} gab.com Text Computational Analysis of the Action of Chloroquine on Short QT Syndrome Variant 1 and Variant 3 in Human Ventricles JO: Annu Int Conf IEEE Eng Med Biol Soc http://www.kidney.de/pget.php?&tw=1&pmid=30441573 #FOAvip AIMS: The short QT syndrome (SQTS) is a rare genetic disorder associated with arrhythmias and sudden cardiac death (SCD). The SQTI and SQT3, SQTS variants, result from gain-of-function mutations (N588K and D172N, respectively) in the KCNH2-encoded and KCNJ2-encoded potassium channels, in which treatment with potassium channel blocking agents has demonstrated some efficacy. This study used in silico modelling to gain mechanistic insights into the actions of anti-malarial drug chloroquine (CQ) in the setting of SQTI and SQT3. METHODS AND RESULTS: The ten Tusscher et al. human ventricle model was modified to a Markov chain formulation of $I_J$<r and a Hodgkin-Huxley formulation of $I_J$<1 describing SQTI and SQT3 mutant conditions, respectively. Cell models were incorporated into heterogeneous one-dimensional (ID) transmural ventricular strand model to assess prolongation of the QT intervals. The blocking effects of CQ on $I_J$<1 and $I_J$<r were modelled by using Hill coefficient and IC(50) from literatures. At the single cells, CQ prolonged the AP duration (APD) under both the SQTI and SQT3 conditions; at the multi-cell strand level, CQ prolonged the QT intervals and declined the T-wave amplitude under both conditions. CONCLUSIONS: This computational study provides novel insights into the efficacy of CQ in the setting of SQTI and SQT3 variants, and indicates that CQ is a useful drug in the treatment of SQTS. Twit Text FOAVip Computational Analysis of the Action of Chloroquine on Short QT Syndrome Variant 1 and Variant 3 in Human Ventricles ????Annu Int Conf IEEE Eng Med Biol Soc http://www.kidney.de/pget.php?&tw=1&pmid=30441573 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30441573 #FOAvip English Wikipedia <ref>{{Cite pmid|30441573}}</ref> Computational Analysis of the Action of Chloroquine on Short QT Syndrome Variant 1 and Variant 3 in Human Ventricles #MMPMID30441573 Luo C; Wang K; Liu T; Zhang H Annu Int Conf IEEE Eng Med Biol Soc 2018[Jul]; 2018 (?): 5462-5465 PMID30441573show ga AIMS: The short QT syndrome (SQTS) is a rare genetic disorder associated with arrhythmias and sudden cardiac death (SCD). The SQTI and SQT3, SQTS variants, result from gain-of-function mutations (N588K and D172N, respectively) in the KCNH2-encoded and KCNJ2-encoded potassium channels, in which treatment with potassium channel blocking agents has demonstrated some efficacy. This study used in silico modelling to gain mechanistic insights into the actions of anti-malarial drug chloroquine (CQ) in the setting of SQTI and SQT3. METHODS AND RESULTS: The ten Tusscher et al. human ventricle model was modified to a Markov chain formulation of $I_J$ |*Arrhythmias, Cardiac[MESH] |Action Potentials[MESH] |Chloroquine[MESH] |Electrocardiography[MESH] |Heart Conduction System[MESH]Computational Analysis of the Action of Chloroquine on Short QT Syndro(epmc).pdf DeepDyve Pubget Overpricing