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10.1111/ane.13052 http://scihub22266oqcxt.onion/10.1111/ane.13052 30428124/?report=reader!6492129!30428124     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Neurol+Scand 2019 ; 139 (3): 305-312 Nephropedia Template TP {{tp|p=30428124|t=2019. Structural correlates of cognitive impairment in normal pressure hydrocephalus |pdf=|usr=}}{{30428124}} gab.com Text Structural correlates of cognitive impairment in normal pressure hydrocephalus JO: Acta Neurol Scand http://www.kidney.de/pget.php?&tw=1&pmid=30428124 #FOAvip OBJECTIVES: The pathological bases for the cognitive and neuropsychiatric symptoms in normal pressure hydrocephalus (NPH) have not been elucidated. However, the symptoms may indicate dysfunction of subcortical regions. Previously, volume reductions of subcortical deep grey matter (SDGM) structures have been observed in NPH patients. The present study used automated segmentation methods to investigate whether SDGM structure volumes are associated with cognitive and neuropsychiatric measures. METHODS: Fourteen NPH patients and eight healthy controls were included in the study. Patients completed neuropsychological tests of general cognition, verbal learning and memory, verbal fluency and measures of apathy and depression pre- and postshunt surgery. Additionally, patients underwent 3 Tesla T1-weighted magnetic resonance imaging at baseline and 6 months postoperatively. Controls were scanned once. SDGM structure volumes were estimated using automated segmentation (FSL FIRST). Since displacement of the caudate nuclei occurred for some patients due to ventriculomegaly, patient caudate volumes were also estimated using manual tracing. Group differences in SDGM structure volumes were investigated, as well as associations between volumes and cognitive and neuropsychiatric measures in patients. RESULTS: Volumes of the caudate, thalamus, putamen, pallidum, hippocampus and nucleus accumbens (NAcc) were significantly reduced in the NPH patients compared to controls. In the NPH group, smaller caudate and NAcc volumes were associated with poorer performance on neuropsychological tests and increased severity of neuropsychiatric symptoms, while reduced volume of the pallidum was associated with better performance on the MMSE and reduced apathy. CONCLUSIONS: Striatal volume loss appears to be associated with cognitive and neuropsychiatric changes in NPH. Twit Text FOAVip Structural correlates of cognitive impairment in normal pressure hydrocephalus ????Acta Neurol Scand http://www.kidney.de/pget.php?&tw=1&pmid=30428124 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30428124 #FOAvip English Wikipedia <ref>{{Cite pmid|30428124}}</ref> Structural correlates of cognitive impairment in normal pressure hydrocephalus #MMPMID30428124 Peterson KA; Mole TB; Keong NCH; DeVito EE; Savulich G; Pickard JD; Sahakian BJ Acta Neurol Scand 2019[Mar]; 139 (3): 305-312 PMID30428124show ga OBJECTIVES: The pathological bases for the cognitive and neuropsychiatric symptoms in normal pressure hydrocephalus (NPH) have not been elucidated. However, the symptoms may indicate dysfunction of subcortical regions. Previously, volume reductions of subcortical deep grey matter (SDGM) structures have been observed in NPH patients. The present study used automated segmentation methods to investigate whether SDGM structure volumes are associated with cognitive and neuropsychiatric measures. METHODS: Fourteen NPH patients and eight healthy controls were included in the study. Patients completed neuropsychological tests of general cognition, verbal learning and memory, verbal fluency and measures of apathy and depression pre- and postshunt surgery. Additionally, patients underwent 3 Tesla T1-weighted magnetic resonance imaging at baseline and 6 months postoperatively. Controls were scanned once. SDGM structure volumes were estimated using automated segmentation (FSL FIRST). Since displacement of the caudate nuclei occurred for some patients due to ventriculomegaly, patient caudate volumes were also estimated using manual tracing. Group differences in SDGM structure volumes were investigated, as well as associations between volumes and cognitive and neuropsychiatric measures in patients. RESULTS: Volumes of the caudate, thalamus, putamen, pallidum, hippocampus and nucleus accumbens (NAcc) were significantly reduced in the NPH patients compared to controls. In the NPH group, smaller caudate and NAcc volumes were associated with poorer performance on neuropsychological tests and increased severity of neuropsychiatric symptoms, while reduced volume of the pallidum was associated with better performance on the MMSE and reduced apathy. CONCLUSIONS: Striatal volume loss appears to be associated with cognitive and neuropsychiatric changes in NPH. |Adult[MESH] |Brain/*pathology[MESH] |Cognitive Dysfunction/*etiology/*pathology[MESH] |Female[MESH] |Humans[MESH] |Hydrocephalus, Normal Pressure/*complications/*pathology/psychology[MESH] |Magnetic Resonance Imaging/methods[MESH] |Male[MESH]Structural correlates of cognitive impairment in normal pressure hydro(epmc).pdf DeepDyve Pubget Overpricing