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10.1016/j.prp.2018.10.030 http://scihub22266oqcxt.onion/10.1016/j.prp.2018.10.030 30396756!ä!30396756 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pathol+Res+Pract 2019 ; 215 (1): 106-114 Nephropedia Template TP {{tp|p=30396756|t=2019. Magnesium isoglycyrrhizinate alleviates liver injury in obese rats with acute necrotizing pancreatitis |pdf=|usr=}}{{30396756}} gab.com Text Magnesium isoglycyrrhizinate alleviates liver injury in obese rats with acute necrotizing pancreatitis JO: Pathol Res Pract http://www.kidney.de/pget.php?&tw=1&pmid=30396756 #FOAvip OBJECTIVE: For patients with acute necrotizing pancreatitis (ANP), a high body mass index (BMI) increases the likelihood of acute hepatic injury (AHI). In the current study, we explored whether magnesium isoglycyrrhizinate (MgIg) could alleviate ANP-induced liver injury in obese rats. METHODS: Sprague-Dawley (SD) rats were selected for the present study, and the ANP model was established by retrograde injection of 5% sodium taurocholate into the biliary-pancreatic duct. Thirty-six SD rats were randomly assigned to six groups: the normal (N), standard rat chow (SRC) normal (SN), SRC ANP (S-ANP), high-fat diet (HFD) normal (H-N), HFD ANP (H-ANP), and MgIg pretreatment HFD ANP (H-ANPT) groups. The rats in the H-ANPT group were treated with MgIg (30 mg/kg) intragastrically for 7 days before the ANP model was established. The rats were sacrificed 12 h after ANP was established, and the blood and pancreatic and liver tissues were collected. Differences in the physiology, pathology and cellular and molecular responses of the rats in each group were examined. RESULT: Analyses of serum amylase lipase, alanine aminotransferase and aspartate aminotransferase indicated that obesity aggravated ANP-induced hepatic injury and that MgIg improved liver function. The superoxide dismutase, malondialdehyde, M1 macrophage, M2 macrophage, neutrophil, NF-kappaB, IL-1beta and caspase-3 levels in liver tissue showed that MgIg attenuated H-ANP-induced hepatic injury by inhibiting oxidative stress and inflammation. CONCLUSION: Obesity aggravated ANP-induced liver injury via oxidative stress and inflammatory reactions. MgIg alleviated oxidative stress and decreased the inflammatory reaction, protecting the liver against the AHI induced by ANP in obese rats. Twit Text FOAVip Magnesium isoglycyrrhizinate alleviates liver injury in obese rats with acute necrotizing pancreatitis ????Pathol Res Pract http://www.kidney.de/pget.php?&tw=1&pmid=30396756 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30396756 #FOAvip English Wikipedia <ref>{{Cite pmid|30396756}}</ref> Magnesium isoglycyrrhizinate alleviates liver injury in obese rats with acute necrotizing pancreatitis #MMPMID30396756 Mei F; Yu J; Li M; Xiang M; Hong Y; Zhou Y; You Y; Xia H; Jin H; Wang W Pathol Res Pract 2019[Jan]; 215 (1): 106-114 PMID30396756show ga OBJECTIVE: For patients with acute necrotizing pancreatitis (ANP), a high body mass index (BMI) increases the likelihood of acute hepatic injury (AHI). In the current study, we explored whether magnesium isoglycyrrhizinate (MgIg) could alleviate ANP-induced liver injury in obese rats. METHODS: Sprague-Dawley (SD) rats were selected for the present study, and the ANP model was established by retrograde injection of 5% sodium taurocholate into the biliary-pancreatic duct. Thirty-six SD rats were randomly assigned to six groups: the normal (N), standard rat chow (SRC) normal (SN), SRC ANP (S-ANP), high-fat diet (HFD) normal (H-N), HFD ANP (H-ANP), and MgIg pretreatment HFD ANP (H-ANPT) groups. The rats in the H-ANPT group were treated with MgIg (30 mg/kg) intragastrically for 7 days before the ANP model was established. The rats were sacrificed 12 h after ANP was established, and the blood and pancreatic and liver tissues were collected. Differences in the physiology, pathology and cellular and molecular responses of the rats in each group were examined. RESULT: Analyses of serum amylase lipase, alanine aminotransferase and aspartate aminotransferase indicated that obesity aggravated ANP-induced hepatic injury and that MgIg improved liver function. The superoxide dismutase, malondialdehyde, M1 macrophage, M2 macrophage, neutrophil, NF-kappaB, IL-1beta and caspase-3 levels in liver tissue showed that MgIg attenuated H-ANP-induced hepatic injury by inhibiting oxidative stress and inflammation. CONCLUSION: Obesity aggravated ANP-induced liver injury via oxidative stress and inflammatory reactions. MgIg alleviated oxidative stress and decreased the inflammatory reaction, protecting the liver against the AHI induced by ANP in obese rats. |Animals[MESH] |Inflammation/drug therapy/pathology[MESH] |Liver/*drug effects/injuries/pathology[MESH] |Male[MESH] |Malondialdehyde/metabolism[MESH] |NF-kappa B/metabolism[MESH] |Neutrophils/*drug effects[MESH] |Obesity/complications/*drug therapy[MESH] |Oxidative Stress/drug effects[MESH] |Pancreas/drug effects/pathology[MESH] |Pancreatitis, Acute Necrotizing/*drug therapy[MESH] |Protective Agents/pharmacology[MESH] |Rats, Sprague-Dawley[MESH] |Saponins/*pharmacology[MESH]Magnesium isoglycyrrhizinate alleviates liver injury in obese rats wit(epmc).pdf DeepDyve Pubget Overpricing