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10.1002/jcb.28041 http://scihub22266oqcxt.onion/10.1002/jcb.28041 30387200!ä!30387200 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Biochem 2019 ; 120 (5): 7667-7678 Nephropedia Template TP {{tp|p=30387200|t=2019. Stabilization of hypoxia-inducible factor 1alpha by cobalt chloride impairs podocyte morphology and slit-diaphragm function |pdf=|usr=}}{{30387200}} gab.com Text Stabilization of hypoxia-inducible factor 1alpha by cobalt chloride impairs podocyte morphology and slit-diaphragm function JO: J Cell Biochem http://www.kidney.de/pget.php?&tw=1&pmid=30387200 #FOAvip Glomerular podocytes are the major components of the renal filtration barrier, and altered podocyte permselectivity is a key event in the pathogenesis of proteinuric conditions. Clinical conditions such as ischemia and sleep apnea and extreme physiological conditions such as high-altitude sickness are presented with renal hypoxia and are associated with significant proteinuria. Hypoxia is considered as an etiological factor in the progression of acute renal injury. A sustained increase in hypoxia-inducible factor 1alpha (HIF1alpha) is a major adaptive stimulus to the hypoxic conditions. Although the temporal association between hypoxia and proteinuria is known, the mechanism by which hypoxia elicits proteinuria remains to be investigated. Furthermore, stabilization of HIF1alpha is being considered as a therapeutic option to treat anemia in patients with chronic kidney disease. Therefore, in this study, we induced stabilization of HIF1alpha in glomerular regions in vivo and in podocytes in vitro upon exposure to cobalt chloride. The elevated HIF1alpha expression is concurrence with diminished expression of nephrin and podocin, podocyte foot-processes effacement, and significant proteinuria. Podocytes exposed to cobalt chloride lost their arborized morphology and cell-cell connections and also displayed cytoskeletal derangements. Elevation in expression of HIF1alpha is in concomitance with loss of nephrin and podocin in patients with diabetic nephropathy and chronic kidney disease. In summary, the current study suggests that HIF1alpha stabilization impairs podocyte function vis-a-vis glomerular permselectivity. Twit Text FOAVip Stabilization of hypoxia-inducible factor 1alpha by cobalt chloride impairs podocyte morphology and slit-diaphragm function ????J Cell Biochem http://www.kidney.de/pget.php?&tw=1&pmid=30387200 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30387200 #FOAvip English Wikipedia <ref>{{Cite pmid|30387200}}</ref> Stabilization of hypoxia-inducible factor 1alpha by cobalt chloride impairs podocyte morphology and slit-diaphragm function #MMPMID30387200 Nakuluri K; Mukhi D; Mungamuri SK; Pasupulati AK J Cell Biochem 2019[May]; 120 (5): 7667-7678 PMID30387200show ga Glomerular podocytes are the major components of the renal filtration barrier, and altered podocyte permselectivity is a key event in the pathogenesis of proteinuric conditions. Clinical conditions such as ischemia and sleep apnea and extreme physiological conditions such as high-altitude sickness are presented with renal hypoxia and are associated with significant proteinuria. Hypoxia is considered as an etiological factor in the progression of acute renal injury. A sustained increase in hypoxia-inducible factor 1alpha (HIF1alpha) is a major adaptive stimulus to the hypoxic conditions. Although the temporal association between hypoxia and proteinuria is known, the mechanism by which hypoxia elicits proteinuria remains to be investigated. Furthermore, stabilization of HIF1alpha is being considered as a therapeutic option to treat anemia in patients with chronic kidney disease. Therefore, in this study, we induced stabilization of HIF1alpha in glomerular regions in vivo and in podocytes in vitro upon exposure to cobalt chloride. The elevated HIF1alpha expression is concurrence with diminished expression of nephrin and podocin, podocyte foot-processes effacement, and significant proteinuria. Podocytes exposed to cobalt chloride lost their arborized morphology and cell-cell connections and also displayed cytoskeletal derangements. Elevation in expression of HIF1alpha is in concomitance with loss of nephrin and podocin in patients with diabetic nephropathy and chronic kidney disease. In summary, the current study suggests that HIF1alpha stabilization impairs podocyte function vis-a-vis glomerular permselectivity. äStabilization of hypoxia-inducible factor 1alpha by cobalt chloride im(epmc).pdf DeepDyve Pubget Overpricing