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10.1002/jnr.24333 http://scihub22266oqcxt.onion/10.1002/jnr.24333 30320448!7167007!30320448     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neurosci+Res 2019 ; 97 (2): 116-127 Nephropedia Template TP {{tp|p=30320448|t=2019. Therapeutic spectrum of interferon-beta in ischemic stroke |pdf=|usr=}}{{30320448}} gab.com Text Therapeutic spectrum of interferon-beta in ischemic stroke JO: J Neurosci Res http://www.kidney.de/pget.php?&tw=1&pmid=30320448 #FOAvip Ischemic stroke is devastating and a major cause of morbidity and mortality worldwide. To date, only clot retrieval devices and/or intravenous tissue plasminogen activators (tPA) have been approved by the US-FDA for the treatment of acute ischemic stroke. Therefore, there is an urgent need to develop an effective treatment for stroke that can have limited shortcomings and broad spectrum of applications. Interferon-beta (IFN-beta), an endogenous cytokine and a key anti-inflammatory agent, contributes toward obviating deleterious stroke outcomes. Therefore, exploring the role of IFN-beta may be a promising alternative approach for stroke intervention in the future. In the present review, we have discussed about IFN-beta along with its different mechanistic roles in ischemic stroke. Furthermore, therapeutic approaches targeting the inflammatory cascade with IFN-beta therapy that may be helpful in improving stroke outcome are also discussed. Twit Text FOAVip Therapeutic spectrum of interferon-beta in ischemic stroke ????J Neurosci Res http://www.kidney.de/pget.php?&tw=1&pmid=30320448 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30320448 #FOAvip English Wikipedia <ref>{{Cite pmid|30320448}}</ref> Therapeutic spectrum of interferon-beta in ischemic stroke #MMPMID30320448 Wanve M; Kaur H; Sarmah D; Saraf J; Pravalika K; Vats K; Kalia K; Borah A; Yavagal DR; Dave KR; Bhattacharya P J Neurosci Res 2019[Feb]; 97 (2): 116-127 PMID30320448show ga Ischemic stroke is devastating and a major cause of morbidity and mortality worldwide. To date, only clot retrieval devices and/or intravenous tissue plasminogen activators (tPA) have been approved by the US-FDA for the treatment of acute ischemic stroke. Therefore, there is an urgent need to develop an effective treatment for stroke that can have limited shortcomings and broad spectrum of applications. Interferon-beta (IFN-beta), an endogenous cytokine and a key anti-inflammatory agent, contributes toward obviating deleterious stroke outcomes. Therefore, exploring the role of IFN-beta may be a promising alternative approach for stroke intervention in the future. In the present review, we have discussed about IFN-beta along with its different mechanistic roles in ischemic stroke. Furthermore, therapeutic approaches targeting the inflammatory cascade with IFN-beta therapy that may be helpful in improving stroke outcome are also discussed. |Animals[MESH] |Brain Ischemia/metabolism/*physiopathology[MESH] |Humans[MESH] |Interferon-beta/classification/metabolism/*physiology[MESH]Therapeutic spectrum of interferon-beta in ischemic stroke (epmc).pdf DeepDyve Pubget Overpricing