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Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cancer+Manag+Res 2018 ; 10 (ä): 3765-3771 Nephropedia Template TP
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The impact of biopsy sampling errors and the quality of surgical margins on local recurrence and survival in chondrosarcoma #MMPMID30288107
Cancer Manag Res 2018[]; 10 (ä): 3765-3771 PMID30288107show ga
PURPOSE: To examine the frequency of computed tomography (CT)-guided biopsy sampling errors in chondrosarcomas, as well as the impact of these errors and the achieved surgical margins on local recurrence-free survival (LRFS) and disease-specific survival (DSS). MATERIAL AND METHODS: A total of 68 consecutive patients treated for chondrosarcoma from 2000-2015 were retrospectively reviewed with a minimum follow-up duration of 2 years. RESULTS: The primary location was at the extremities in 46 patients (67.6%) and at the axial skeleton in 22 patients (32.4%). Seven patients underwent planned intralesional curettage. Surgical margins were assessed in the remaining 53 patients and included 21 wide (39.6%), 25 marginal (47.1%), and seven intralesional (13.2%) resections. Biopsy sampling errors occurred in ten patients (14.7%). LRFS was 82.2+/-7.8% at 5 years and 76.9+/-7.8% at 10 years. An intact anatomical barrier was associated with the most preferable LRFS of 89+/-10.5% after 10 years. DSS was 79.2+/-8.5% at 5 years and 75.5+/-6.4% at 10 years. The metric distance of the surgical margin and the presence of a biopsy sampling error did not affect either LRFS or DSS. CONCLUSION: Even though histological grading in chondrosarcoma is difficult, sampling errors in preoperative biopsies are relatively rare and do not adversely affect outcomes. The presence of an anatomical barrier has a greater impact on LRFS than the metric distance of the surgical margins.