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10.1007/s00228-018-2557-7 http://scihub22266oqcxt.onion/10.1007/s00228-018-2557-7 30259065!ä!30259065 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Clin+Pharmacol 2019 ; 75 (1): 59-66 Nephropedia Template TP {{tp|p=30259065|t=2019. Prospective study of serum and ionized magnesium pharmacokinetics in the treatment of children with severe acute asthma |pdf=|usr=}}{{30259065}} gab.com Text Prospective study of serum and ionized magnesium pharmacokinetics in the treatment of children with severe acute asthma JO: Eur J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=30259065 #FOAvip PURPOSE: Intravenous (IV) magnesium sulfate (MgSO(4)) is clinically useful as adjunct therapy in treating acute asthma exacerbations. Despite its clinical utility, the disposition of magnesium in children is poorly described. The purpose of this study is to describe the pharmacokinetics (PK) of ionized and total serum magnesium following IV MgSO(4) administration in children with severe acute asthma. METHODS: Thirty-two children receiving 50 mg/kg IV MgSO(4) for acute asthma exacerbations at Primary Children's Hospital in Salt Lake City, UT, were prospectively enrolled in the study. Blood samples were collected before, as well as 30 min and 2 h after each child's IV MgSO(4) dose, and used to determine total serum and ionized magnesium concentrations. The collected data were analyzed using population PK techniques using NONMEM(R) software. RESULTS: Total serum magnesium concentrations were used to externally validate our previously published model constructed with retrospective data (median prediction error 10.3%, median absolute prediction error 18.1%). The mean (%CV) observed endogenous ionized magnesium concentration was calculated to be 6.0 mg/L (12%), approximately one third of the same value for endogenous total serum magnesium (17.6 mg/L (22%)) in this dataset. Weight was a significant predictor of both clearance and volume in a population PK model describing ionized magnesium concentrations. No adverse events were observed in this pediatric cohort. CONCLUSIONS: This prospective study supports and extends our previous PK analysis of total serum magnesium concentrations. Ionized and total serum magnesium followed similar PK profiles following IV MgSO(4) administration in children. A single bolus infusion of IV MgSO(4) was safe in this small sample of children receiving it for acute asthma. Twit Text FOAVip Prospective study of serum and ionized magnesium pharmacokinetics in the treatment of children with severe acute asthma ????Eur J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=30259065 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30259065 #FOAvip English Wikipedia <ref>{{Cite pmid|30259065}}</ref> Prospective study of serum and ionized magnesium pharmacokinetics in the treatment of children with severe acute asthma #MMPMID30259065 Becker SM; Job KM; Lima K; Forbes TJ; Wagstaff J; Tran NK; Sherwin CM; Nelson DS; Johnson MD; Rower JE Eur J Clin Pharmacol 2019[Jan]; 75 (1): 59-66 PMID30259065show ga PURPOSE: Intravenous (IV) magnesium sulfate (MgSO(4)) is clinically useful as adjunct therapy in treating acute asthma exacerbations. Despite its clinical utility, the disposition of magnesium in children is poorly described. The purpose of this study is to describe the pharmacokinetics (PK) of ionized and total serum magnesium following IV MgSO(4) administration in children with severe acute asthma. METHODS: Thirty-two children receiving 50 mg/kg IV MgSO(4) for acute asthma exacerbations at Primary Children's Hospital in Salt Lake City, UT, were prospectively enrolled in the study. Blood samples were collected before, as well as 30 min and 2 h after each child's IV MgSO(4) dose, and used to determine total serum and ionized magnesium concentrations. The collected data were analyzed using population PK techniques using NONMEM(R) software. RESULTS: Total serum magnesium concentrations were used to externally validate our previously published model constructed with retrospective data (median prediction error 10.3%, median absolute prediction error 18.1%). The mean (%CV) observed endogenous ionized magnesium concentration was calculated to be 6.0 mg/L (12%), approximately one third of the same value for endogenous total serum magnesium (17.6 mg/L (22%)) in this dataset. Weight was a significant predictor of both clearance and volume in a population PK model describing ionized magnesium concentrations. No adverse events were observed in this pediatric cohort. CONCLUSIONS: This prospective study supports and extends our previous PK analysis of total serum magnesium concentrations. Ionized and total serum magnesium followed similar PK profiles following IV MgSO(4) administration in children. A single bolus infusion of IV MgSO(4) was safe in this small sample of children receiving it for acute asthma. |*Models, Biological[MESH] |Acute Disease[MESH] |Adolescent[MESH] |Anti-Asthmatic Agents/*administration & dosage/adverse effects/pharmacokinetics[MESH] |Asthma/*drug therapy/physiopathology[MESH] |Child[MESH] |Child, Preschool[MESH] |Female[MESH] |Hospitalization[MESH] |Humans[MESH] |Infusions, Intravenous[MESH] |Magnesium Sulfate/*administration & dosage/adverse effects/pharmacokinetics[MESH] |Male[MESH] |Prospective Studies[MESH] |Severity of Illness Index[MESH]Prospective study of serum and ionized magnesium pharmacokinetics in t(epmc).pdf DeepDyve Pubget Overpricing