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10.1080/2162402X.2018.1469594 http://scihub22266oqcxt.onion/10.1080/2162402X.2018.1469594 30228937!6140587!30228937     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30228937&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Oncoimmunology 2018 ; 7 (9): e1469594 Nephropedia Template TP {{tp|p=30228937|t=2018. VISTA is highly expressed on MDSCs and mediates an inhibition of T cell response in patients with AML |pdf=|usr=}}{{30228937}} gab.com Text VISTA is highly expressed on MDSCs and mediates an inhibition of T cell response in patients with AML JO: Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=30228937 #FOAvip Treatment of acute myeloid leukemia (AML) remains challenging. Enhancement of anti-tumor responses by blocking negative immune regulators is a promising strategy for novel effective leukemia therapeutics. V-domain Ig suppressor of T-cell activation (VISTA) is a recently defined negative regulator mediating immune evasion in cancer. To investigate the effect of VISTA on anti-leukemia immune response in AML, we initiated a study using clinical samples collected from AML patients. Here we report that VISTA is highly expressed on myeloid-derived suppressor cells (MDSCs) in the peripheral blood of AML patients. Both the frequency and intensity of VISTA expression on MDSCs are significantly higher in newly diagnosed AML than in healthy controls. Importantly knockdown of VISTA by specific siRNA potently reduced the MDSCs-mediated inhibition of CD8 T cell activity in AML, suggesting a suppressive effect of VISTA on anti-leukemia T cell response. Furthermore, we observed a strong positive association between MDSC expression of VISTA and T cell expression of PD-1 in AML. These results support the strategy of VISTA-targeted treatment for AML and underscore the strong potential for combined blockade of VISTA and PD-1 pathways in effective leukemia control. Twit Text FOAVip VISTA is highly expressed on MDSCs and mediates an inhibition of T cell response in patients with AML ????Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=30228937 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30228937 #FOAvip English Wikipedia <ref>{{Cite pmid|30228937}}</ref> VISTA is highly expressed on MDSCs and mediates an inhibition of T cell response in patients with AML #MMPMID30228937 Wang L; Jia B; Claxton DF; Ehmann WC; Rybka WB; Mineishi S; Naik S; Khawaja MR; Sivik J; Han J; Hohl RJ; Zheng H Oncoimmunology 2018[]; 7 (9): e1469594 PMID30228937show ga Treatment of acute myeloid leukemia (AML) remains challenging. Enhancement of anti-tumor responses by blocking negative immune regulators is a promising strategy for novel effective leukemia therapeutics. V-domain Ig suppressor of T-cell activation (VISTA) is a recently defined negative regulator mediating immune evasion in cancer. To investigate the effect of VISTA on anti-leukemia immune response in AML, we initiated a study using clinical samples collected from AML patients. Here we report that VISTA is highly expressed on myeloid-derived suppressor cells (MDSCs) in the peripheral blood of AML patients. Both the frequency and intensity of VISTA expression on MDSCs are significantly higher in newly diagnosed AML than in healthy controls. Importantly knockdown of VISTA by specific siRNA potently reduced the MDSCs-mediated inhibition of CD8 T cell activity in AML, suggesting a suppressive effect of VISTA on anti-leukemia T cell response. Furthermore, we observed a strong positive association between MDSC expression of VISTA and T cell expression of PD-1 in AML. These results support the strategy of VISTA-targeted treatment for AML and underscore the strong potential for combined blockade of VISTA and PD-1 pathways in effective leukemia control. ?VISTA is highly expressed on MDSCs and mediates an inhibition of T cel(epmc).pdf DeepDyve Pubget Overpricing