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10.1136/thoraxjnl-2018-211916 http://scihub22266oqcxt.onion/10.1136/thoraxjnl-2018-211916 30228207!ä!30228207 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Thorax 2019 ; 74 (3): 305-308 Nephropedia Template TP {{tp|p=30228207|t=2019. Progranulin aggravates pulmonary immunopathology during influenza virus infection |pdf=|usr=}}{{30228207}} gab.com Text Progranulin aggravates pulmonary immunopathology during influenza virus infection JO: Thorax http://www.kidney.de/pget.php?&tw=1&pmid=30228207 #FOAvip Progranulin (PGRN) exerts multiple functions in various inflammatory diseases. However, the role of PGRN in the pathogenesis of virus infection is unknown. Here, we demonstrated that PGRN production was up-regulated in clinical and experimental influenza, which contributed to the deleterious inflammatory response after influenza virus infection in mice. PGRN-deficient mice were protected from influenza virus-induced lung injury and mortality. Decreased mortality was associated with significantly reduced influx of neutrophils and monocytes/macrophages, release of cytokines and chemokines, and permeability of the alveolar-epithelial barrier without affecting viral clearance. Our findings suggest that PGRN exacerbates pulmonary immunopathology during influenza virus infection. Twit Text FOAVip Progranulin aggravates pulmonary immunopathology during influenza virus infection ????Thorax http://www.kidney.de/pget.php?&tw=1&pmid=30228207 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30228207 #FOAvip English Wikipedia <ref>{{Cite pmid|30228207}}</ref> Progranulin aggravates pulmonary immunopathology during influenza virus infection #MMPMID30228207 Luo Q; Yan X; Tu H; Yin Y; Cao J Thorax 2019[Mar]; 74 (3): 305-308 PMID30228207show ga Progranulin (PGRN) exerts multiple functions in various inflammatory diseases. However, the role of PGRN in the pathogenesis of virus infection is unknown. Here, we demonstrated that PGRN production was up-regulated in clinical and experimental influenza, which contributed to the deleterious inflammatory response after influenza virus infection in mice. PGRN-deficient mice were protected from influenza virus-induced lung injury and mortality. Decreased mortality was associated with significantly reduced influx of neutrophils and monocytes/macrophages, release of cytokines and chemokines, and permeability of the alveolar-epithelial barrier without affecting viral clearance. Our findings suggest that PGRN exacerbates pulmonary immunopathology during influenza virus infection. |*Influenza A Virus, H1N1 Subtype[MESH] |Animals[MESH] |Case-Control Studies[MESH] |Disease Models, Animal[MESH] |Humans[MESH] |Influenza, Human/*immunology/metabolism/*pathology[MESH] |Mice, Knockout[MESH]Progranulin aggravates pulmonary immunopathology during influenza viru(epmc).pdf DeepDyve Pubget Overpricing