Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41598-018-32065-2 http://scihub22266oqcxt.onion/10.1038/s41598-018-32065-2 30209259!6135842!30209259     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2018 ; 8 (1): 13701 Nephropedia Template TP {{tp|p=30209259|t=2018. Increased Phosphaturia Accelerates The Decline in Renal Function: A Search for Mechanisms |pdf=|usr=}}{{30209259}} gab.com Text Increased Phosphaturia Accelerates The Decline in Renal Function: A Search for Mechanisms JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30209259 #FOAvip In chronic kidney disease (CKD), high serum phosphate concentration is associated with cardiovascular disease and deterioration in renal function. In early CKD, the serum phosphate concentration is normal due to increased fractional excretion of phosphate. Our premise was that high phosphate intake even in patients with early CKD would result in an excessive load of phosphate causing tubular injury and accelerating renal function deterioration. In CKD 2-3 patients, we evaluated whether increased phosphaturia accelerates CKD progression. To have a uniform group of patients with early CKD, 95 patients with metabolic syndrome without overt proteinuria were followed for 2.7 +/- 1.6 years. The median decline in eGFR was 0.50 ml/min/1.73 m(2)/year. Patients with a more rapid decrease in eGFR had greater phosphaturia. Moreover, the rate of decrease in eGFR inversely correlated with the degree of phosphaturia. Additionally, phosphaturia independently predicted renal function deterioration. In heminephrectomized rats, a high phosphate diet increased phosphaturia resulting in renal tubular damage associated with inflammation, oxidative stress and low klotho expression. Moreover, in rats with hyperphosphatemia and metabolic syndrome antioxidant treatment resulted in attenuation of renal lesions. In HEK-293 cells, high phosphate promoted oxidative stress while melatonin administration reduced ROS generation. Our findings suggest that phosphate loading in early CKD, results in renal damage and a more rapid decrease in renal function due to renal tubular injury. Twit Text FOAVip Increased Phosphaturia Accelerates The Decline in Renal Function: A Search for Mechanisms ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30209259 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30209259 #FOAvip English Wikipedia <ref>{{Cite pmid|30209259}}</ref> Increased Phosphaturia Accelerates The Decline in Renal Function: A Search for Mechanisms #MMPMID30209259 Santamaria R; Diaz-Tocados JM; Pendon-Ruiz de Mier MV; Robles A; Salmeron-Rodriguez MD; Ruiz E; Vergara N; Aguilera-Tejero E; Raya A; Ortega R; Felsenfeld A; Munoz-Castaneda JR; Martin-Malo A; Aljama P; Rodriguez M Sci Rep 2018[Sep]; 8 (1): 13701 PMID30209259show ga In chronic kidney disease (CKD), high serum phosphate concentration is associated with cardiovascular disease and deterioration in renal function. In early CKD, the serum phosphate concentration is normal due to increased fractional excretion of phosphate. Our premise was that high phosphate intake even in patients with early CKD would result in an excessive load of phosphate causing tubular injury and accelerating renal function deterioration. In CKD 2-3 patients, we evaluated whether increased phosphaturia accelerates CKD progression. To have a uniform group of patients with early CKD, 95 patients with metabolic syndrome without overt proteinuria were followed for 2.7 +/- 1.6 years. The median decline in eGFR was 0.50 ml/min/1.73 m(2)/year. Patients with a more rapid decrease in eGFR had greater phosphaturia. Moreover, the rate of decrease in eGFR inversely correlated with the degree of phosphaturia. Additionally, phosphaturia independently predicted renal function deterioration. In heminephrectomized rats, a high phosphate diet increased phosphaturia resulting in renal tubular damage associated with inflammation, oxidative stress and low klotho expression. Moreover, in rats with hyperphosphatemia and metabolic syndrome antioxidant treatment resulted in attenuation of renal lesions. In HEK-293 cells, high phosphate promoted oxidative stress while melatonin administration reduced ROS generation. Our findings suggest that phosphate loading in early CKD, results in renal damage and a more rapid decrease in renal function due to renal tubular injury. |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Animals[MESH] |Antioxidants/metabolism[MESH] |Cell Line[MESH] |Female[MESH] |Glomerular Filtration Rate/drug effects/physiology[MESH] |Glucuronidase/metabolism[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Hyperphosphatemia/metabolism/physiopathology[MESH] |Hypophosphatemia, Familial/metabolism/*physiopathology[MESH] |Kidney/drug effects/metabolism/*physiopathology[MESH] |Klotho Proteins[MESH] |Male[MESH] |Melatonin/pharmacology[MESH] |Metabolic Syndrome/metabolism/physiopathology[MESH] |Middle Aged[MESH] |Oxidative Stress/drug effects/physiology[MESH] |Phosphates/metabolism[MESH] |Proteinuria/metabolism/physiopathology[MESH] |Rats[MESH] |Rats, Wistar[MESH] |Rats, Zucker[MESH] |Reactive Oxygen Species/metabolism[MESH] |Renal Insufficiency, Chronic/metabolism/physiopathology[MESH]Increased Phosphaturia Accelerates The Decline in Renal Function: A Se(epmc).pdf DeepDyve Pubget Overpricing