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10.1016/j.bbrc.2018.09.018 http://scihub22266oqcxt.onion/10.1016/j.bbrc.2018.09.018 30205954!ä!30205954 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Res+Commun 2018 ; 504 (2): 538-544 Nephropedia Template TP {{tp|p=30205954|t=2018. Indoxyl glucuronide, a protein-bound uremic toxin, inhibits hypoxia-inducible factor?dependent erythropoietin expression through activation of aryl hydrocarbon receptor |pdf=|usr=}}{{30205954}} gab.com Text Indoxyl glucuronide, a protein-bound uremic toxin, inhibits hypoxia-inducible factor dependent erythropoietin expression through activation of aryl hydrocarbon receptor JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=30205954 #FOAvip Renal anemia is common among chronic kidney disease (CKD) patients, and is mainly caused by inadequate erythropoietin (EPO) production from kidneys due to dysfunction of intracellular hypoxia-inducible factor (HIF) signaling in renal EPO-producing cells. We have previously shown that indoxyl sulfate (IS), a representative protein-bound uremic toxin accumulated in the blood of CKD patients, inhibits hypoxia-induced HIF activation and subsequent EPO production through activation of aryl hydrocarbon receptor (AHR). In this study, we further investigated the effects of other protein-bound uremic toxins on HIF-dependent EPO expression using EPO-producing HepG2 cells. We found that indoxyl glucuronide (IG) and IS, but not p-cresyl sulfate, phenyl sulfate, 3-indoleacetic acid or hippuric acid, inhibited hypoxia mimetic cobalt chloride-induced EPO mRNA expression. Furthermore, IG at concentrations similar to the blood levels in CKD patients inhibited the transcriptional activation of HIF induced by both cobalt chloride treatment and hypoxic culture. IG also induced CYP1A1 mRNA expression and nuclear translocation of AHR protein, indicating that IG activates AHR signaling. Blockade of AHR by a pharmacological antagonist CH-223191 abolished the IG-induced inhibition of HIF activation. Collectively, this study is the first to elucidate the biological effects of IG to inhibit HIF-dependent EPO production through activation of AHR. Our data suggests that not only IS but also IG contributes to the impairment of HIF signaling in renal anemia. Twit Text FOAVip Indoxyl glucuronide, a protein-bound uremic toxin, inhibits hypoxia-inducible factor dependent erythropoietin expression through activation of aryl hydrocarbon receptor ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=30205954 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30205954 #FOAvip English Wikipedia <ref>{{Cite pmid|30205954}}</ref> Indoxyl glucuronide, a protein-bound uremic toxin, inhibits hypoxia-inducible factor?dependent erythropoietin expression through activation of aryl hydrocarbon receptor #MMPMID30205954 Asai H; Hirata J; Watanabe-Akanuma M Biochem Biophys Res Commun 2018[Oct]; 504 (2): 538-544 PMID30205954show ga Renal anemia is common among chronic kidney disease (CKD) patients, and is mainly caused by inadequate erythropoietin (EPO) production from kidneys due to dysfunction of intracellular hypoxia-inducible factor (HIF) signaling in renal EPO-producing cells. We have previously shown that indoxyl sulfate (IS), a representative protein-bound uremic toxin accumulated in the blood of CKD patients, inhibits hypoxia-induced HIF activation and subsequent EPO production through activation of aryl hydrocarbon receptor (AHR). In this study, we further investigated the effects of other protein-bound uremic toxins on HIF-dependent EPO expression using EPO-producing HepG2 cells. We found that indoxyl glucuronide (IG) and IS, but not p-cresyl sulfate, phenyl sulfate, 3-indoleacetic acid or hippuric acid, inhibited hypoxia mimetic cobalt chloride-induced EPO mRNA expression. Furthermore, IG at concentrations similar to the blood levels in CKD patients inhibited the transcriptional activation of HIF induced by both cobalt chloride treatment and hypoxic culture. IG also induced CYP1A1 mRNA expression and nuclear translocation of AHR protein, indicating that IG activates AHR signaling. Blockade of AHR by a pharmacological antagonist CH-223191 abolished the IG-induced inhibition of HIF activation. Collectively, this study is the first to elucidate the biological effects of IG to inhibit HIF-dependent EPO production through activation of AHR. Our data suggests that not only IS but also IG contributes to the impairment of HIF signaling in renal anemia. |Cell Survival[MESH] |Cytochrome P-450 CYP1A1/metabolism[MESH] |Erythropoietin/*antagonists & inhibitors[MESH] |Gene Expression Regulation[MESH] |Glucuronates/*pharmacology[MESH] |Hep G2 Cells[MESH] |Humans[MESH] |Indican/metabolism[MESH] |Indoles/*pharmacology[MESH] |Protein Binding[MESH] |Receptors, Aryl Hydrocarbon/*metabolism[MESH] |Renal Insufficiency, Chronic/therapy[MESH] |Signal Transduction[MESH] |Transcriptional Activation[MESH]Indoxyl glucuronide, a protein-bound uremic toxin, inhibits hypoxia-in(epmc).pdf DeepDyve Pubget Overpricing