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10.1016/j.jsps.2018.04.005 http://scihub22266oqcxt.onion/10.1016/j.jsps.2018.04.005 30202218!6128724!30202218     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Saudi+Pharm+J 2018 ; 26 (6): 786-789 Nephropedia Template TP {{tp|p=30202218|t=2018. Vitamin B12 protects against DNA damage induced by hydrochlorothiazide |pdf=|usr=}}{{30202218}} gab.com Text Vitamin B12 protects against DNA damage induced by hydrochlorothiazide JO: Saudi Pharm J http://www.kidney.de/pget.php?&tw=1&pmid=30202218 #FOAvip DNA damage induced by hydrochlorothiazide was previously reported in cultured human lymphocytes. In this study, we aimed to investigate the harmful effects of hydrochlorothiazide on DNA by measuring the spontaneous frequency of sister chromatid exchanges (SCEs) in cultured human lymphocytes. We also aimed to investigate the possible protection of that damage by vitamin B12. The results showed that hydrochlorothiazide (5?microg/mL) significantly increased the frequency of sister chromatid exchanges (P?<?0.001) in human lymphocytes in comparison with control. Additionally, the frequency of hydrochlorothiazide-induced SCEs was significantly decreased by co-treatment with vitamin B12 at concentration of 13.5?microg/mL (P?<?0.001). In conclusion, hydrochlorothiazide is genotoxic to human lymphocytes and its toxicity is reduced by vitamin B12. Twit Text FOAVip Vitamin B12 protects against DNA damage induced by hydrochlorothiazide ????Saudi Pharm J http://www.kidney.de/pget.php?&tw=1&pmid=30202218 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30202218 #FOAvip English Wikipedia <ref>{{Cite pmid|30202218}}</ref> Vitamin B12 protects against DNA damage induced by hydrochlorothiazide #MMPMID30202218 Alzoubi KH; Bayraktar E; Khabour O; Al-Azzam SI Saudi Pharm J 2018[Sep]; 26 (6): 786-789 PMID30202218show ga DNA damage induced by hydrochlorothiazide was previously reported in cultured human lymphocytes. In this study, we aimed to investigate the harmful effects of hydrochlorothiazide on DNA by measuring the spontaneous frequency of sister chromatid exchanges (SCEs) in cultured human lymphocytes. We also aimed to investigate the possible protection of that damage by vitamin B12. The results showed that hydrochlorothiazide (5?microg/mL) significantly increased the frequency of sister chromatid exchanges (P? äVitamin B12 protects against DNA damage induced by hydrochlorothiazide(epmc).pdf DeepDyve Pubget Overpricing