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10.1021/acs.chemrev.8b00201 http://scihub22266oqcxt.onion/10.1021/acs.chemrev.8b00201 30192523!6405328!30192523     free     free     free       Chem+Rev 2019 ; 119 (2): 1323-1455 Nephropedia Template TP {{tp|p=30192523|t=2019. Targeting Metalloenzymes for Therapeutic Intervention |pdf=|usr=}}{{30192523}} gab.com Text Targeting Metalloenzymes for Therapeutic Intervention JO: Chem Rev http://www.kidney.de/pget.php?&tw=1&pmid=30192523 #FOAvip Metalloenzymes are central to a wide range of essential biological activities, including nucleic acid modification, protein degradation, and many others. The role of metalloenzymes in these processes also makes them central for the progression of many diseases and, as such, makes metalloenzymes attractive targets for therapeutic intervention. Increasing awareness of the role metalloenzymes play in disease and their importance as a class of targets has amplified interest in the development of new strategies to develop inhibitors and ultimately useful drugs. In this Review, we provide a broad overview of several drug discovery efforts focused on metalloenzymes and attempt to map out the current landscape of high-value metalloenzyme targets. Twit Text FOAVip Targeting Metalloenzymes for Therapeutic Intervention ????Chem Rev http://www.kidney.de/pget.php?&tw=1&pmid=30192523 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30192523 #FOAvip English Wikipedia <ref>{{Cite pmid|30192523}}</ref> Targeting Metalloenzymes for Therapeutic Intervention #MMPMID30192523 Chen AY; Adamek RN; Dick BL; Credille CV; Morrison CN; Cohen SM Chem Rev 2019[Jan]; 119 (2): 1323-1455 PMID30192523show ga Metalloenzymes are central to a wide range of essential biological activities, including nucleic acid modification, protein degradation, and many others. The role of metalloenzymes in these processes also makes them central for the progression of many diseases and, as such, makes metalloenzymes attractive targets for therapeutic intervention. Increasing awareness of the role metalloenzymes play in disease and their importance as a class of targets has amplified interest in the development of new strategies to develop inhibitors and ultimately useful drugs. In this Review, we provide a broad overview of several drug discovery efforts focused on metalloenzymes and attempt to map out the current landscape of high-value metalloenzyme targets. |Carbonic Anhydrases/chemistry/metabolism[MESH] |Catalytic Domain[MESH] |Drug Discovery[MESH] |Enzyme Inhibitors/chemistry/metabolism/*therapeutic use[MESH] |Matrix Metalloproteinases/chemistry/metabolism[MESH] |Metalloproteins/antagonists & inhibitors/*metabolism[MESH] |Oxidoreductases/antagonists & inhibitors/metabolism[MESH] |Peptide Hydrolases/chemistry/metabolism[MESH] |Transferases/antagonists & inhibitors/metabolism[MESH]Targeting Metalloenzymes for Therapeutic Intervention (epmc).pdf DeepDyve Pubget Overpricing