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10.1038/s41593-018-0206-1 http://scihub22266oqcxt.onion/10.1038/s41593-018-0206-1 30150663!6386176!30150663     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Neurosci 2018 ; 21 (9): 1161-1170 Nephropedia Template TP {{tp|p=30150663|t=2018. GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia |pdf=|usr=}}{{30150663}} gab.com Text GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia JO: Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=30150663 #FOAvip Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (N = 184,765), we identified eight genome-wide significant independent single nucleotide polymorphisms in six regions. All measured genetic variants combined explained 11% of the variance. Gene-based tests revealed 35 significant genes in 16 regions, and S-PrediXcan analyses showed that 21 genes had different expression levels for cannabis users versus nonusers. The strongest finding across the different analyses was CADM2, which has been associated with substance use and risk-taking. Significant genetic correlations were found with 14 of 25 tested substance use and mental health-related traits, including smoking, alcohol use, schizophrenia and risk-taking. Mendelian randomization analysis showed evidence for a causal positive influence of schizophrenia risk on cannabis use. Overall, our study provides new insights into the etiology of cannabis use and its relation with mental health. Twit Text FOAVip GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia ????Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=30150663 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30150663 #FOAvip English Wikipedia <ref>{{Cite pmid|30150663}}</ref> GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia #MMPMID30150663 Pasman JA; Verweij KJH; Gerring Z; Stringer S; Sanchez-Roige S; Treur JL; Abdellaoui A; Nivard MG; Baselmans BML; Ong JS; Ip HF; van der Zee MD; Bartels M; Day FR; Fontanillas P; Elson SL; de Wit H; Davis LK; MacKillop J; Derringer JL; Branje SJT; Hartman CA; Heath AC; van Lier PAC; Madden PAF; Magi R; Meeus W; Montgomery GW; Oldehinkel AJ; Pausova Z; Ramos-Quiroga JA; Paus T; Ribases M; Kaprio J; Boks MPM; Bell JT; Spector TD; Gelernter J; Boomsma DI; Martin NG; MacGregor S; Perry JRB; Palmer AA; Posthuma D; Munafo MR; Gillespie NA; Derks EM; Vink JM Nat Neurosci 2018[Sep]; 21 (9): 1161-1170 PMID30150663show ga Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (N = 184,765), we identified eight genome-wide significant independent single nucleotide polymorphisms in six regions. All measured genetic variants combined explained 11% of the variance. Gene-based tests revealed 35 significant genes in 16 regions, and S-PrediXcan analyses showed that 21 genes had different expression levels for cannabis users versus nonusers. The strongest finding across the different analyses was CADM2, which has been associated with substance use and risk-taking. Significant genetic correlations were found with 14 of 25 tested substance use and mental health-related traits, including smoking, alcohol use, schizophrenia and risk-taking. Mendelian randomization analysis showed evidence for a causal positive influence of schizophrenia risk on cannabis use. Overall, our study provides new insights into the etiology of cannabis use and its relation with mental health. |*Genome-Wide Association Study[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Cell Adhesion Molecules/genetics[MESH] |Databases, Genetic[MESH] |Female[MESH] |Gene Expression Regulation/genetics[MESH] |Genetic Predisposition to Disease[MESH] |Genotype[MESH] |Humans[MESH] |Male[MESH] |Marijuana Abuse/*genetics/*psychology[MESH] |Mendelian Randomization Analysis[MESH] |Mental Health[MESH] |Middle Aged[MESH] |Polymorphism, Single Nucleotide[MESH] |Risk-Taking[MESH] |Schizophrenia/*chemically induced/*genetics[MESH]GWAS of lifetime cannabis use reveals new risk loci, genetic overlap w(epmc).pdf DeepDyve Pubget Overpricing