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10.14336/AD.2018.0702 http://scihub22266oqcxt.onion/10.14336/AD.2018.0702 30090664/?report=reader!6065299!30090664     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Aging+Dis 2018 ; 9 (4): 761-768 Nephropedia Template TP {{tp|p=30090664|t=2018. Hypoxia, hibernation and Neuroprotection: An Experimental Study in Mice |pdf=|usr=}}{{30090664}} gab.com Text Hypoxia, hibernation and Neuroprotection: An Experimental Study in Mice JO: Aging Dis http://www.kidney.de/pget.php?&tw=1&pmid=30090664 #FOAvip Hibernation is a unique physiological state that evolved to survive periods of food shortages. It is characterized by profound decreases in metabolic rate, body temperature and physiological functions. Studies have shown that animals in hibernation can resist neurological damage. Here, we aimed to study whether hypoxia can induce a hibernation-like state in a traditionally non-hibernating animal and whether it is neuroprotective. All procedures were conducted according to international guidelines on laboratory animal safety. Mice C57BL/6 (19-21g) were placed into a 125 mL jar with fresh air and the jar was sealed with a rubber plug. For each run, the tolerance limit was judged by the animals' appearance for "air hunger". The animal was removed from the jar as soon as its first gasping breath appeared and was moved to another fresh-air-containing jar of similar volume. This procedure was performed in four runs. The hypoxia exposure significantly decreased oxygen (O(2)) consumption, carbon dioxide (CO(2)) production, respiratory rate and heart rate. Meanwhile, rectal temperature reached a minimum of 12.7+/-2.56 degrees C, which is lower than a wide range of ambient temperatures. The mimicked hibernation decreased the infarct size in a focal cerebral ischemia mouse model. Our findings suggest the possibility of inducing suspended animation-like hibernation states for medical applications post injury. Twit Text FOAVip Hypoxia, hibernation and Neuroprotection: An Experimental Study in Mice ????Aging Dis http://www.kidney.de/pget.php?&tw=1&pmid=30090664 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30090664 #FOAvip English Wikipedia <ref>{{Cite pmid|30090664}}</ref> Hypoxia, hibernation and Neuroprotection: An Experimental Study in Mice #MMPMID30090664 Ren C; Li S; Rajah G; Shao G; Lu G; Han R; Huang Q; Li H; Ding Y; Jin K; Ji X Aging Dis 2018[Aug]; 9 (4): 761-768 PMID30090664show ga Hibernation is a unique physiological state that evolved to survive periods of food shortages. It is characterized by profound decreases in metabolic rate, body temperature and physiological functions. Studies have shown that animals in hibernation can resist neurological damage. Here, we aimed to study whether hypoxia can induce a hibernation-like state in a traditionally non-hibernating animal and whether it is neuroprotective. All procedures were conducted according to international guidelines on laboratory animal safety. Mice C57BL/6 (19-21g) were placed into a 125 mL jar with fresh air and the jar was sealed with a rubber plug. For each run, the tolerance limit was judged by the animals' appearance for "air hunger". The animal was removed from the jar as soon as its first gasping breath appeared and was moved to another fresh-air-containing jar of similar volume. This procedure was performed in four runs. The hypoxia exposure significantly decreased oxygen (O(2)) consumption, carbon dioxide (CO(2)) production, respiratory rate and heart rate. Meanwhile, rectal temperature reached a minimum of 12.7+/-2.56 degrees C, which is lower than a wide range of ambient temperatures. The mimicked hibernation decreased the infarct size in a focal cerebral ischemia mouse model. Our findings suggest the possibility of inducing suspended animation-like hibernation states for medical applications post injury. äHypoxia, hibernation and Neuroprotection: An Experimental Study in Mic(epmc).pdf DeepDyve Pubget Overpricing