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10.1016/j.colsurfb.2018.07.032 http://scihub22266oqcxt.onion/10.1016/j.colsurfb.2018.07.032 30041151!ä!30041151 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Colloids+Surf+B+Biointerfaces 2018 ; 171 (ä): 276-284 Nephropedia Template TP {{tp|p=30041151|t=2018. Reduced inflammatory response by incorporating magnesium into porous TiO(2) coating on titanium substrate |pdf=|usr=}}{{30041151}} gab.com Text Reduced inflammatory response by incorporating magnesium into porous TiO(2) coating on titanium substrate JO: Colloids Surf B Biointerfaces http://www.kidney.de/pget.php?&tw=1&pmid=30041151 #FOAvip The implant materials with proper anti-inflammatory and osteogenic properties may be promising for orthopedic applications. The inflammatory response induced by biomaterials has been regarded as one of the critical factors in determining in vivo fate of implants. Therefore, a novel bone biomaterial should have inflammation regulatory effects instead of being completely bio-inert. In the present work, the inflammation regulatory effects of exogenous magnesium (Mg) ions were investigated. Under the stimulation of lipopolysaccharide (LPS), macrophages exposed to Mg(2+) exhibited down-regulated gene expressions of M1 markers (CD86, CD11c and inducible nitric oxide synthase (iNOS)) and pro-inflammatory cytokines (tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and IL-1beta), up-regulated gene expression of M2 marker CD163 and decreased TNF-alpha release, indicating that Mg(2+) could switch macrophages from M1 to M2 phenotype. Thereafter, micro-arc oxidation (MAO) technique was employed to fabricate Mg-containing ceramic coatings on titanium substrates. Macrophages grown on Mg-containing surface were switched from M1 to M2 phenotype with the stimulation of LPS, evidenced by suppressed gene expressions of M1 markers (CD86, CD11c and iNOS) and pro-inflammatory cytokines (TNF-alpha and IL-1beta), promoted gene expression of M2 marker CD163 and decreased TNF-alpha release. Moreover, gene expressions of bone morphogenetic protein-2 (BMP-2), BMP-6 and vascular endothelial growth factor (VEGF) were up-regulated on Mg incorporated MAO surface without LPS stimulation. Together, Mg could be used as an anti-inflammatory agent for suppressing inflammation and mediating osteogenesis. The integration of Mg in biomaterials could endow bone biomaterials with anti-inflammatory property. Twit Text FOAVip Reduced inflammatory response by incorporating magnesium into porous TiO(2) coating on titanium substrate ????Colloids Surf B Biointerfaces http://www.kidney.de/pget.php?&tw=1&pmid=30041151 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30041151 #FOAvip English Wikipedia <ref>{{Cite pmid|30041151}}</ref> Reduced inflammatory response by incorporating magnesium into porous TiO(2) coating on titanium substrate #MMPMID30041151 Li X; Huang Q; Liu L; Zhu W; Elkhooly TA; Liu Y; Feng Q; Li Q; Zhou S; Liu Y; Wu H Colloids Surf B Biointerfaces 2018[Nov]; 171 (ä): 276-284 PMID30041151show ga The implant materials with proper anti-inflammatory and osteogenic properties may be promising for orthopedic applications. The inflammatory response induced by biomaterials has been regarded as one of the critical factors in determining in vivo fate of implants. Therefore, a novel bone biomaterial should have inflammation regulatory effects instead of being completely bio-inert. In the present work, the inflammation regulatory effects of exogenous magnesium (Mg) ions were investigated. Under the stimulation of lipopolysaccharide (LPS), macrophages exposed to Mg(2+) exhibited down-regulated gene expressions of M1 markers (CD86, CD11c and inducible nitric oxide synthase (iNOS)) and pro-inflammatory cytokines (tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and IL-1beta), up-regulated gene expression of M2 marker CD163 and decreased TNF-alpha release, indicating that Mg(2+) could switch macrophages from M1 to M2 phenotype. Thereafter, micro-arc oxidation (MAO) technique was employed to fabricate Mg-containing ceramic coatings on titanium substrates. Macrophages grown on Mg-containing surface were switched from M1 to M2 phenotype with the stimulation of LPS, evidenced by suppressed gene expressions of M1 markers (CD86, CD11c and iNOS) and pro-inflammatory cytokines (TNF-alpha and IL-1beta), promoted gene expression of M2 marker CD163 and decreased TNF-alpha release. Moreover, gene expressions of bone morphogenetic protein-2 (BMP-2), BMP-6 and vascular endothelial growth factor (VEGF) were up-regulated on Mg incorporated MAO surface without LPS stimulation. Together, Mg could be used as an anti-inflammatory agent for suppressing inflammation and mediating osteogenesis. The integration of Mg in biomaterials could endow bone biomaterials with anti-inflammatory property. |Adsorption[MESH] |Animals[MESH] |Cell Proliferation/drug effects[MESH] |Cells, Cultured[MESH] |Inflammation/*drug therapy/metabolism[MESH] |Macrophages/*drug effects/metabolism[MESH] |Magnesium/chemistry/*pharmacology[MESH] |Mice[MESH] |Particle Size[MESH] |Porosity[MESH] |RAW 264.7 Cells[MESH] |Surface Properties[MESH]Reduced inflammatory response by incorporating magnesium into porous T(epmc).pdf DeepDyve Pubget Overpricing