Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.jash.2018.06.018 http://scihub22266oqcxt.onion/10.1016/j.jash.2018.06.018 30033123!6139275!30033123     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30033123&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Am+Soc+Hypertens 2018 ; 12 (9): 681-689 Nephropedia Template TP {{tp|p=30033123|t=2018. Aldosterone, inactive matrix gla-protein, and large artery stiffness in hypertension |pdf=|usr=}}{{30033123}} gab.com Text Aldosterone, inactive matrix gla-protein, and large artery stiffness in hypertension JO: J Am Soc Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=30033123 #FOAvip Vascular calcification leads to increased large artery stiffness. Matrix gla-protein (MGP) is a vitamin K-dependent protein that inhibits arterial calcification. Aldosterone promotes vascular calcification and stiffness, but the relationships between aldosterone, MGP, and arterial stiffness are unknown. We studied 199 adults (predominantly older men) with hypertension. We assessed the relationship between levels of dephospho-uncarboxylated MGP (dp-ucMGP), aldosterone, and carotid-femoral pulse wave velocity (CF-PWV) using standard regression and mediation analyses. Plasma aldosterone was measured in a subgroup of subjects (n = 106). Aldosterone was strongly associated with dp-ucMGP (standardized beta = 0.50, P < .001), which was independent of potential confounders (beta = 0.37, P < .001). Levels of dp-ucMGP were significantly associated with CF-PWV (beta = 0.30; P < .001), which persisted after adjustment for potential confounders (beta = 0.25; P = .004). Plasma aldosterone was also significantly associated with CF-PWV (standardized beta = 0.21; P = .035). However, in a model that included aldosterone and dp-ucMGP, only the latter was associated with CF-PWV. Mediation analyses demonstrated a significant dp-ucMGP-mediated effect of aldosterone on CF-PWV, without a significant direct (dp-ucMGP independent) effect. Our study demonstrates a novel independent association between high aldosterone levels and dp-ucMGP, suggesting that aldosterone may influence the MGP pathway. This relationship appears to underlie the previously documented relationship between aldosterone and increased arterial stiffness. Twit Text FOAVip Aldosterone, inactive matrix gla-protein, and large artery stiffness in hypertension ????J Am Soc Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=30033123 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30033123 #FOAvip English Wikipedia <ref>{{Cite pmid|30033123}}</ref> Aldosterone, inactive matrix gla-protein, and large artery stiffness in hypertension #MMPMID30033123 Chirinos JA; Sardana M; Syed AA; Koppula MR; Varakantam S; Vasim I; Oldland HG; Phan TS; Drummen NEA; Vermeer C; Townsend RR; Akers SR; Wei W; Lakatta EG; Fedorova OV J Am Soc Hypertens 2018[Sep]; 12 (9): 681-689 PMID30033123show ga Vascular calcification leads to increased large artery stiffness. Matrix gla-protein (MGP) is a vitamin K-dependent protein that inhibits arterial calcification. Aldosterone promotes vascular calcification and stiffness, but the relationships between aldosterone, MGP, and arterial stiffness are unknown. We studied 199 adults (predominantly older men) with hypertension. We assessed the relationship between levels of dephospho-uncarboxylated MGP (dp-ucMGP), aldosterone, and carotid-femoral pulse wave velocity (CF-PWV) using standard regression and mediation analyses. Plasma aldosterone was measured in a subgroup of subjects (n = 106). Aldosterone was strongly associated with dp-ucMGP (standardized beta = 0.50, P < .001), which was independent of potential confounders (beta = 0.37, P < .001). Levels of dp-ucMGP were significantly associated with CF-PWV (beta = 0.30; P < .001), which persisted after adjustment for potential confounders (beta = 0.25; P = .004). Plasma aldosterone was also significantly associated with CF-PWV (standardized beta = 0.21; P = .035). However, in a model that included aldosterone and dp-ucMGP, only the latter was associated with CF-PWV. Mediation analyses demonstrated a significant dp-ucMGP-mediated effect of aldosterone on CF-PWV, without a significant direct (dp-ucMGP independent) effect. Our study demonstrates a novel independent association between high aldosterone levels and dp-ucMGP, suggesting that aldosterone may influence the MGP pathway. This relationship appears to underlie the previously documented relationship between aldosterone and increased arterial stiffness. ?Aldosterone, inactive matrix gla-protein, and large artery stiffness i(epmc).pdf DeepDyve Pubget Overpricing