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10.1111/ajt.15026 http://scihub22266oqcxt.onion/10.1111/ajt.15026 30019411!?!30019411       Am+J+Transplant 2018 ; 18 (12): 3029-3037 Nephropedia Template TP {{tp|p=30019411|t=2018. Glucocorticoids induce corneal allograft tolerance through expansion of monocytic myeloid-derived suppressor cells |pdf=|usr=}}{{30019411}} gab.com Text Glucocorticoids induce corneal allograft tolerance through expansion of monocytic myeloid-derived suppressor cells JO: Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=30019411 #FOAvip Glucocorticoids (GCs) are the most widely used drugs to prevent transplant rejection; however, it is not yet clear how GCs induce immune tolerance in transplantation. Here, we demonstrate that GCs induce tolerance to corneal allografts in mice through expansion of MHC class II(-) CD11b(+) Ly6C(+) monocytes in the bone marrow and mobilization of the cells to spleen, draining lymph nodes, and graft site. The GC-induced CD11b(+) Ly6C(+) monocytes inhibited T cell proliferation in vitro, and adoptive transfer of the cells improved the survival of corneal allografts. Depletion of CD11b(+) Ly6C(+) cells in mice during GC treatment abrogated the effects of GCs in prevention of immune rejection. Together, the results identify monocytic myeloid-derived suppressor cells as crucial mediators of the GC-induced tolerance in transplantation. Twit Text FOAVip Glucocorticoids induce corneal allograft tolerance through expansion of monocytic myeloid-derived suppressor cells ????Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=30019411 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30019411 #FOAvip English Wikipedia <ref>{{Cite pmid|30019411}}</ref> Glucocorticoids induce corneal allograft tolerance through expansion of monocytic myeloid-derived suppressor cells #MMPMID30019411 Lee HJ; Park SY; Jeong HJ; Kim HJ; Kim MK; Oh JY Am J Transplant 2018[Dec]; 18 (12): 3029-3037 PMID30019411show ga Glucocorticoids (GCs) are the most widely used drugs to prevent transplant rejection; however, it is not yet clear how GCs induce immune tolerance in transplantation. Here, we demonstrate that GCs induce tolerance to corneal allografts in mice through expansion of MHC class II(-) CD11b(+) Ly6C(+) monocytes in the bone marrow and mobilization of the cells to spleen, draining lymph nodes, and graft site. The GC-induced CD11b(+) Ly6C(+) monocytes inhibited T cell proliferation in vitro, and adoptive transfer of the cells improved the survival of corneal allografts. Depletion of CD11b(+) Ly6C(+) cells in mice during GC treatment abrogated the effects of GCs in prevention of immune rejection. Together, the results identify monocytic myeloid-derived suppressor cells as crucial mediators of the GC-induced tolerance in transplantation. |Allografts[MESH] |Animals[MESH] |CD4-Positive T-Lymphocytes/drug effects/immunology[MESH] |Corneal Transplantation/*adverse effects[MESH] |Glucocorticoids/*administration & dosage[MESH] |Graft Rejection/etiology/*prevention & control[MESH] |Graft Survival/drug effects/*immunology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mice, Inbred C57BL[MESH] |Monocytes/*cytology/drug effects[MESH] |Myeloid-Derived Suppressor Cells/*cytology/drug effects/transplantation[MESH]Glucocorticoids induce corneal allograft tolerance through expansion o(epmc).pdf DeepDyve Pubget Overpricing