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10.1016/j.bbamcr.2018.07.004 http://scihub22266oqcxt.onion/10.1016/j.bbamcr.2018.07.004 30009861!6335178!30009861     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30009861&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Biochim+Biophys+Acta+Mol+Cell+Res 2018 ; 1865 (11 Pt B): 1698-1706 Nephropedia Template TP {{tp|p=30009861|t=2018. Differential regulation of ion channels function by proteolysis |pdf=|usr=}}{{30009861}} gab.com Text Differential regulation of ion channels function by proteolysis JO: Biochim Biophys Acta Mol Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=30009861 #FOAvip Ion channels are pore-forming protein complexes in membranes that play essential roles in a diverse array of biological activities. Ion channel activity is strictly regulated at multiple levels and by numerous cellular events to selectively activate downstream effectors involved in specific biological activities. For example, ions, binding proteins, nucleotides, phosphorylation, the redox state, channel subunit composition have all been shown to regulate channel activity and subsequently allow channels to participate in distinct cellular events. While these forms of modulation are well documented and have been extensively reviewed, in this article, we will first review and summarize channel proteolysis as a novel and quite widespread mechanism for altering channel activity. We will then highlight the recent findings demonstrating that proteolysis profoundly alters Inositol 1,4,5 trisphosphate receptor activity, and then discuss its potential functional ramifications in various developmental and pathological conditions. Twit Text FOAVip Differential regulation of ion channels function by proteolysis ????Biochim Biophys Acta Mol Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=30009861 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30009861 #FOAvip English Wikipedia <ref>{{Cite pmid|30009861}}</ref> Differential regulation of ion channels function by proteolysis #MMPMID30009861 Wang L; Yule DI Biochim Biophys Acta Mol Cell Res 2018[Nov]; 1865 (11 Pt B): 1698-1706 PMID30009861show ga Ion channels are pore-forming protein complexes in membranes that play essential roles in a diverse array of biological activities. Ion channel activity is strictly regulated at multiple levels and by numerous cellular events to selectively activate downstream effectors involved in specific biological activities. For example, ions, binding proteins, nucleotides, phosphorylation, the redox state, channel subunit composition have all been shown to regulate channel activity and subsequently allow channels to participate in distinct cellular events. While these forms of modulation are well documented and have been extensively reviewed, in this article, we will first review and summarize channel proteolysis as a novel and quite widespread mechanism for altering channel activity. We will then highlight the recent findings demonstrating that proteolysis profoundly alters Inositol 1,4,5 trisphosphate receptor activity, and then discuss its potential functional ramifications in various developmental and pathological conditions. |*Ion Channel Gating[MESH] |*Protein Processing, Post-Translational[MESH] |Animals[MESH] |Calcium Signaling[MESH] |Calcium/metabolism[MESH] |Disease Susceptibility[MESH] |Humans[MESH] |Inositol 1,4,5-Trisphosphate Receptors/metabolism[MESH] |Ion Channels/agonists/antagonists & inhibitors/genetics/*metabolism[MESH]Differential regulation of ion channels function by proteolysis (epmc).pdf DeepDyve Pubget Overpricing