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10.1016/j.biopha.2018.06.102 http://scihub22266oqcxt.onion/10.1016/j.biopha.2018.06.102 29957470!ä!29957470 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Pharmacother 2018 ; 106 (ä): 83-91 Nephropedia Template TP {{tp|p=29957470|t=2018. The inhibition of Hippo/Yap signaling pathway is required for magnesium isoglycyrrhizinate to ameliorate hepatic stellate cell inflammation and activation |pdf=|usr=}}{{29957470}} gab.com Text The inhibition of Hippo/Yap signaling pathway is required for magnesium isoglycyrrhizinate to ameliorate hepatic stellate cell inflammation and activation JO: Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=29957470 #FOAvip Liver fibrosis is a reversible pathological process accompanied by abnormal inflammation, and its end-stage cirrhosis is responsible for high morbidity and mortality worldwide. This study was to investigate the effect of Magnesium isoglycyrrhizinate (MgIG) on liver fibrosis and inflammation, and to further clarify molecular mechanism. We found that MgIG treatment significantly alleviated carbon tetrachloride (CCl(4))-induced liver fibrosis and HSC activation by regulating TGF-beta signaling and MMP/TIMP systems. In addition, MgIG treatment significantly inhibited the inflammatory response of liver fibrosis in mice characterized by reduced pro-inflammatory factors expression and increased anti-inflammatory factors expression. Interestingly, experiments in vitro also showed that MgIG treatment significantly reduced the expression of hepatic stellate cell (HSC) activation markers. Besides, MgIG treatment not only inhibited the expression of pro-inflammatory factors, but also promoted the production of anti-inflammatory factors in activated HSCs. Importantly, treatment with MgIG inhibited Hippo/Yap signaling pathway, which was a potential mechanism for MgIG-induced anti-inflammatory effects. The overexpression of Hippo/Yap signaling effector YAP completely impaired MgIG-induced anti-inflammatory and anti-fibrotic effects. Taken together, these results provide novel implications to reveal the molecular mechanism of the anti-inflammatory properties induced by MgIG, by which points to the possibility of using MgIG to treat liver fibrosis. Twit Text FOAVip The inhibition of Hippo/Yap signaling pathway is required for magnesium isoglycyrrhizinate to ameliorate hepatic stellate cell inflammation and activation ????Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=29957470 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29957470 #FOAvip English Wikipedia <ref>{{Cite pmid|29957470}}</ref> The inhibition of Hippo/Yap signaling pathway is required for magnesium isoglycyrrhizinate to ameliorate hepatic stellate cell inflammation and activation #MMPMID29957470 Li L; Zhou J; Li Q; Xu J; Qi J; Bian H Biomed Pharmacother 2018[Oct]; 106 (ä): 83-91 PMID29957470show ga Liver fibrosis is a reversible pathological process accompanied by abnormal inflammation, and its end-stage cirrhosis is responsible for high morbidity and mortality worldwide. This study was to investigate the effect of Magnesium isoglycyrrhizinate (MgIG) on liver fibrosis and inflammation, and to further clarify molecular mechanism. We found that MgIG treatment significantly alleviated carbon tetrachloride (CCl(4))-induced liver fibrosis and HSC activation by regulating TGF-beta signaling and MMP/TIMP systems. In addition, MgIG treatment significantly inhibited the inflammatory response of liver fibrosis in mice characterized by reduced pro-inflammatory factors expression and increased anti-inflammatory factors expression. Interestingly, experiments in vitro also showed that MgIG treatment significantly reduced the expression of hepatic stellate cell (HSC) activation markers. Besides, MgIG treatment not only inhibited the expression of pro-inflammatory factors, but also promoted the production of anti-inflammatory factors in activated HSCs. Importantly, treatment with MgIG inhibited Hippo/Yap signaling pathway, which was a potential mechanism for MgIG-induced anti-inflammatory effects. The overexpression of Hippo/Yap signaling effector YAP completely impaired MgIG-induced anti-inflammatory and anti-fibrotic effects. Taken together, these results provide novel implications to reveal the molecular mechanism of the anti-inflammatory properties induced by MgIG, by which points to the possibility of using MgIG to treat liver fibrosis. |Adaptor Proteins, Signal Transducing/*metabolism[MESH] |Animals[MESH] |Anti-Inflammatory Agents/*pharmacology[MESH] |Becaplermin/pharmacology[MESH] |Carbon Tetrachloride[MESH] |Cell Cycle Proteins[MESH] |Chemical and Drug Induced Liver Injury/etiology/metabolism/pathology/*prevention & control[MESH] |Cytokines/metabolism[MESH] |Hepatic Stellate Cells/*drug effects/metabolism/pathology[MESH] |Hippo Signaling Pathway[MESH] |Inflammation Mediators/metabolism[MESH] |Liver Cirrhosis, Experimental/chemically induced/metabolism/pathology/*prevention & control[MESH] |Liver/*drug effects/metabolism/pathology[MESH] |Male[MESH] |Mice, Inbred C57BL[MESH] |NF-kappa B/metabolism[MESH] |Phosphoproteins/*metabolism[MESH] |Protein Serine-Threonine Kinases/*metabolism[MESH] |Saponins/*pharmacology[MESH] |Signal Transduction/*drug effects[MESH] |Triterpenes/*pharmacology[MESH]The inhibition of Hippo/Yap signaling pathway is required for magnesiu(epmc).pdf DeepDyve Pubget Overpricing