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10.1016/j.lfs.2018.06.022 http://scihub22266oqcxt.onion/10.1016/j.lfs.2018.06.022 29940240!ä!29940240 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Life+Sci 2018 ; 207 (ä): 436-441 Nephropedia Template TP {{tp|p=29940240|t=2018. Protective effects of magnesium sulfate against doxorubicin induced cardiotoxicity in rats |pdf=|usr=}}{{29940240}} gab.com Text Protective effects of magnesium sulfate against doxorubicin induced cardiotoxicity in rats JO: Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=29940240 #FOAvip AIMS: Clinical use of doxorubicin, an effective chemotherapeutic agent, has limited uses due to dose-dependent cardiac toxicity. It has been supposed that the production of free radicals and calcium ions overload can lead to cardiac toxicity. Magnesium is a cardioprotective drug which inhibits lipid peroxidation and reducing myocardial apoptosis. This study was aimed to explore the hypothesis that the cardiac toxicity induced by administration of doxorubicin is prevented or reduced by magnesium sulfate treatment and if so, whether this is associated with altered oxidative stress response in heart. MATERIAL AND METHODS: Male Wistar rats were intraperitoneally injected with doxorubicin and magnesium sulfate and normal saline four times per week for 2 consecutive weeks. Then electrocardiographic, inotropic and biochemical tests were performed. KEY FINDINGS: Co-administration of magnesium sulfate with doxorubicin significantly reversed alterations in the stimulation threshold and contractile force induced by doxorubicin. In addition, magnesium sulfate improved body weight loss and alleviated the mortality rate of animals induced by doxorubicin. Moreover, it was observed that lesions induced by doxorubicin decreased in animals treated with magnesium sulfate. Magnesium sulfate significantly increased Glutathione (GSH) in doxorubicin treated animals. SIGNIFICANCE: In conclusion, the results of the present study demonstrated that magnesium sulfate attenuate the cardio toxic effects of doxorubicin by increasing the activities of the antioxidants enzyme. Twit Text FOAVip Protective effects of magnesium sulfate against doxorubicin induced cardiotoxicity in rats ????Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=29940240 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29940240 #FOAvip English Wikipedia <ref>{{Cite pmid|29940240}}</ref> Protective effects of magnesium sulfate against doxorubicin induced cardiotoxicity in rats #MMPMID29940240 Khalilzadeh M; Abdollahi A; Abdolahi F; Abdolghaffari AH; Dehpour AR; Jazaeri F Life Sci 2018[Aug]; 207 (ä): 436-441 PMID29940240show ga AIMS: Clinical use of doxorubicin, an effective chemotherapeutic agent, has limited uses due to dose-dependent cardiac toxicity. It has been supposed that the production of free radicals and calcium ions overload can lead to cardiac toxicity. Magnesium is a cardioprotective drug which inhibits lipid peroxidation and reducing myocardial apoptosis. This study was aimed to explore the hypothesis that the cardiac toxicity induced by administration of doxorubicin is prevented or reduced by magnesium sulfate treatment and if so, whether this is associated with altered oxidative stress response in heart. MATERIAL AND METHODS: Male Wistar rats were intraperitoneally injected with doxorubicin and magnesium sulfate and normal saline four times per week for 2 consecutive weeks. Then electrocardiographic, inotropic and biochemical tests were performed. KEY FINDINGS: Co-administration of magnesium sulfate with doxorubicin significantly reversed alterations in the stimulation threshold and contractile force induced by doxorubicin. In addition, magnesium sulfate improved body weight loss and alleviated the mortality rate of animals induced by doxorubicin. Moreover, it was observed that lesions induced by doxorubicin decreased in animals treated with magnesium sulfate. Magnesium sulfate significantly increased Glutathione (GSH) in doxorubicin treated animals. SIGNIFICANCE: In conclusion, the results of the present study demonstrated that magnesium sulfate attenuate the cardio toxic effects of doxorubicin by increasing the activities of the antioxidants enzyme. |Animals[MESH] |Antioxidants/chemistry[MESH] |Body Weight[MESH] |Calcium/chemistry[MESH] |Cardiotoxicity/*prevention & control[MESH] |Doxorubicin/*adverse effects[MESH] |Electrocardiography[MESH] |Free Radicals[MESH] |Glutathione/metabolism[MESH] |Heart Ventricles/drug effects[MESH] |Heart/*drug effects[MESH] |Ions[MESH] |Magnesium Sulfate/*pharmacology[MESH] |Male[MESH] |Muscle Contraction[MESH] |Myocardium/metabolism[MESH] |Oxidative Stress[MESH] |Oxygen/chemistry[MESH] |Rats[MESH]Protective effects of magnesium sulfate against doxorubicin induced c(epmc).pdf DeepDyve Pubget Overpricing