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10.1002/anie.201806159 http://scihub22266oqcxt.onion/10.1002/anie.201806159 29923670!ä!29923670 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Angew+Chem+Int+Ed+Engl 2018 ; 57 (31): 9875-9879 Nephropedia Template TP {{tp|p=29923670|t=2018. An In Situ Depot for Continuous Evolution of Gaseous H(2) Mediated by a Magnesium Passivation/Activation Cycle for Treating Osteoarthritis |pdf=|usr=}}{{29923670}} gab.com Text An In Situ Depot for Continuous Evolution of Gaseous H(2) Mediated by a Magnesium Passivation/Activation Cycle for Treating Osteoarthritis JO: Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=29923670 #FOAvip Inflammation is involved in many human pathologies, including osteoarthritis (OA). Hydrogen (H(2) ) is known to have anti-inflammatory effects; however, the bioavailability of directly administered H(2) gas is typically poor. Herein, a local delivery system that can provide a high therapeutic concentration of gaseous H(2) at inflamed tissues is proposed. The delivery system comprises poly(lactic-co-glycolic acid) microparticles that contain magnesium powder (Mg@PLGA MPs). Mg@PLGA MPs that are intra-muscularly injected close to the OA knee in a mouse model can act as an in situ depot that can evolve gaseous H(2) continuously, mediated by the cycle of passivation/activation of Mg in body fluids, at a concentration that exceeds its therapeutic threshold. The analytical data that are obtained in the biochemical and histological studies indicate that the proposed Mg@PLGA MPs can effectively mitigate tissue inflammation and prevent cartilage from destruction, arresting the progression of OA changes. Twit Text FOAVip An In Situ Depot for Continuous Evolution of Gaseous H(2) Mediated by a Magnesium Passivation/Activation Cycle for Treating Osteoarthritis ????Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=29923670 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29923670 #FOAvip English Wikipedia <ref>{{Cite pmid|29923670}}</ref> An In Situ Depot for Continuous Evolution of Gaseous H(2) Mediated by a Magnesium Passivation/Activation Cycle for Treating Osteoarthritis #MMPMID29923670 Wan WL; Lin YJ; Shih PC; Bow YR; Cui Q; Chang Y; Chia WT; Sung HW Angew Chem Int Ed Engl 2018[Jul]; 57 (31): 9875-9879 PMID29923670show ga Inflammation is involved in many human pathologies, including osteoarthritis (OA). Hydrogen (H(2) ) is known to have anti-inflammatory effects; however, the bioavailability of directly administered H(2) gas is typically poor. Herein, a local delivery system that can provide a high therapeutic concentration of gaseous H(2) at inflamed tissues is proposed. The delivery system comprises poly(lactic-co-glycolic acid) microparticles that contain magnesium powder (Mg@PLGA MPs). Mg@PLGA MPs that are intra-muscularly injected close to the OA knee in a mouse model can act as an in situ depot that can evolve gaseous H(2) continuously, mediated by the cycle of passivation/activation of Mg in body fluids, at a concentration that exceeds its therapeutic threshold. The analytical data that are obtained in the biochemical and histological studies indicate that the proposed Mg@PLGA MPs can effectively mitigate tissue inflammation and prevent cartilage from destruction, arresting the progression of OA changes. |Animals[MESH] |Humans[MESH] |Hydrogen/*chemistry[MESH] |Magnesium/chemistry/*therapeutic use[MESH] |Mice[MESH] |Organometallic Compounds/chemical synthesis/chemistry/*therapeutic use[MESH] |Osteoarthritis/*drug therapy/metabolism/pathology[MESH] |Particle Size[MESH] |Polylactic Acid-Polyglycolic Acid Copolymer/chemistry/*therapeutic use[MESH] |RAW 264.7 Cells[MESH]An In Situ Depot for Continuous Evolution of Gaseous H(2) Mediated by (epmc).pdf DeepDyve Pubget Overpricing