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10.1152/physrev.00038.2017 http://scihub22266oqcxt.onion/10.1152/physrev.00038.2017 29873596!6335102!29873596     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29873596&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Physiol+Rev 2018 ; 98 (3): 1627-1738 Nephropedia Template TP {{tp|p=29873596|t=2018. Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology |pdf=|usr=}}{{29873596}} gab.com Text Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology JO: Physiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=29873596 #FOAvip The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology and pathophysiology. However, many of the signaling mechanisms have been unclear. The angiotensin II (ANG II) type 1 receptor (AT(1)R) is believed to mediate most functions of ANG II in the system. AT(1)R utilizes various signal transduction cascades causing hypertension, cardiovascular remodeling, and end organ damage. Moreover, functional cross-talk between AT(1)R signaling pathways and other signaling pathways have been recognized. Accumulating evidence reveals the complexity of ANG II signal transduction in pathophysiology of the vasculature, heart, kidney, and brain, as well as several pathophysiological features, including inflammation, metabolic dysfunction, and aging. In this review, we provide a comprehensive update of the ANG II receptor signaling events and their functional significances for potential translation into therapeutic strategies. AT(1)R remains central to the system in mediating physiological and pathophysiological functions of ANG II, and participation of specific signaling pathways becomes much clearer. There are still certain limitations and many controversies, and several noteworthy new concepts require further support. However, it is expected that rigorous translational research of the ANG II signaling pathways including those in large animals and humans will contribute to establishing effective new therapies against various diseases. Twit Text FOAVip Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology ????Physiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=29873596 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29873596 #FOAvip English Wikipedia <ref>{{Cite pmid|29873596}}</ref> Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology #MMPMID29873596 Forrester SJ; Booz GW; Sigmund CD; Coffman TM; Kawai T; Rizzo V; Scalia R; Eguchi S Physiol Rev 2018[Jul]; 98 (3): 1627-1738 PMID29873596show ga The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology and pathophysiology. However, many of the signaling mechanisms have been unclear. The angiotensin II (ANG II) type 1 receptor (AT(1)R) is believed to mediate most functions of ANG II in the system. AT(1)R utilizes various signal transduction cascades causing hypertension, cardiovascular remodeling, and end organ damage. Moreover, functional cross-talk between AT(1)R signaling pathways and other signaling pathways have been recognized. Accumulating evidence reveals the complexity of ANG II signal transduction in pathophysiology of the vasculature, heart, kidney, and brain, as well as several pathophysiological features, including inflammation, metabolic dysfunction, and aging. In this review, we provide a comprehensive update of the ANG II receptor signaling events and their functional significances for potential translation into therapeutic strategies. AT(1)R remains central to the system in mediating physiological and pathophysiological functions of ANG II, and participation of specific signaling pathways becomes much clearer. There are still certain limitations and many controversies, and several noteworthy new concepts require further support. However, it is expected that rigorous translational research of the ANG II signaling pathways including those in large animals and humans will contribute to establishing effective new therapies against various diseases. |*Signal Transduction[MESH] |Adipocytes/metabolism[MESH] |Angiotensin II/*metabolism[MESH] |Animals[MESH] |Blood Vessels/metabolism[MESH] |Brain/metabolism[MESH] |Heart Diseases/metabolism[MESH] |Humans[MESH] |Inflammation/metabolism[MESH] |Kidney Diseases/metabolism[MESH] |Kidney/metabolism[MESH]Angiotensin II Signal Transduction: An Update on Mechanisms of Physiol(epmc).pdf DeepDyve Pubget Overpricing