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10.1007/s10517-018-4098-6

http://scihub22266oqcxt.onion/10.1007/s10517-018-4098-6
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29796811!ä!29796811

suck abstract from ncbi


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pmid29796811      Bull+Exp+Biol+Med 2018 ; 165 (1): 57-60
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  • Preventive Effects of Oxidized Dextran on Functional Activity of Pulmonary Macrophages in Mice Infected with Influenza A Virus #MMPMID29796811
  • Potapova OV; Cherdantseva LA; Kovner AV; Sharkova TV; Troitskii AV; Shestopalov AM; Shkurupy VA
  • Bull Exp Biol Med 2018[May]; 165 (1): 57-60 PMID29796811show ga
  • We analyzed cytokine profile of pulmonary macrophages in mice infected with highly pathogenic influenza A/H5N1 virus after preventive injections of oxidized dextran. Light microscopy, immunohistochemistry, and morphometric examinations showed that preventive injections of oxidized dextran led to more effective virus elimination, modulation of the proinflammatory cytokine response, and host antiviral response and reduce animal mortality. Our findings allow recommending oxidized dextran for further studies in order to create a vaccine with antiviral and adjuvant potencies.
  • |Animals[MESH]
  • |Antiviral Agents/chemistry/*therapeutic use[MESH]
  • |Dextrans/chemistry/*therapeutic use[MESH]
  • |Influenza A Virus, H5N1 Subtype/drug effects/pathogenicity[MESH]
  • |Influenza A virus/*drug effects/*pathogenicity[MESH]
  • |Macrophages, Alveolar/*virology[MESH]
  • |Male[MESH]
  • |Mice[MESH]
  • |Nitric Oxide Synthase/metabolism[MESH]
  • |Orthomyxoviridae Infections/drug therapy/prevention & control[MESH]


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