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10.3390/ijms19051496

http://scihub22266oqcxt.onion/10.3390/ijms19051496
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29772777!5983711!29772777
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suck abstract from ncbi


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pmid29772777      Int+J+Mol+Sci 2018 ; 19 (5): ä
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  • Oxidative Stress in Preeclampsia and Placental Diseases #MMPMID29772777
  • Aouache R; Biquard L; Vaiman D; Miralles F
  • Int J Mol Sci 2018[May]; 19 (5): ä PMID29772777show ga
  • Preeclampsia is a persistent hypertensive gestational disease characterized by high blood pressure and proteinuria, which presents from the second trimester of pregnancy. At the cellular level, preeclampsia has largely been associated with the release of free radicals by the placenta. Placenta-borne oxidative and nitrosative stresses are even sometimes considered as the major molecular determinants of the maternal disease. In this review, we present the recent literature evaluating free radical production in both normal and pathological placentas (including preeclampsia and other major pregnancy diseases), in humans and animal models. We then assess the putative effects of these free radicals on the placenta and maternal endothelium. This analysis was conducted with regard to recent papers and possible therapeutic avenues.
  • |*Oxidative Stress[MESH]
  • |Animals[MESH]
  • |Disease Models, Animal[MESH]
  • |Disease Susceptibility[MESH]
  • |Endothelium, Vascular/metabolism[MESH]
  • |Female[MESH]
  • |Free Radicals/metabolism[MESH]
  • |Humans[MESH]
  • |Oxidation-Reduction[MESH]
  • |Placenta Diseases/etiology/*metabolism/pathology[MESH]
  • |Placenta/metabolism/pathology[MESH]
  • |Pre-Eclampsia/etiology/*metabolism/pathology[MESH]
  • |Pregnancy[MESH]


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