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10.1111/tbed.12904 http://scihub22266oqcxt.onion/10.1111/tbed.12904 29770590!7169816!29770590     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29770590&cmd=llinks): Failed to open stream: HTTP request failed! 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Genomic and antigenic characterization of porcine epidemic diarrhoea virus strains isolated from South Korea, 2017 |pdf=|usr=}}{{29770590}} gab.com Text Genomic and antigenic characterization of porcine epidemic diarrhoea virus strains isolated from South Korea, 2017 JO: Transbound Emerg Dis http://www.kidney.de/pget.php?&tw=1&pmid=29770590 #FOAvip Porcine epidemic diarrhoea virus (PEDV) is a globally emerging and re-emerging enteric coronavirus in pigs causing serious economic threats to the world swine industry. Since the re-emergence of massive PEDV outbreaks in South Korea in 2013-2014, domestic pig farms have continued to experience PED epidemics or endemics. This study represents the molecular characterization of PEDV isolates identified in diarrhoeic animals collected across the country in 2017. Initial sequencing analysis of the full-length S genes revealed that 70% of the 2017 isolates (7/10) belong to the G2b subgroup, while the remaining isolates were classified as G1b. The data indicated that both variant G1b and global epidemic G2b strains were responsible for current PED outbreaks in South Korea. The 2017 G1b and G2b isolates shared 98.7%-99.4% and 98.1%-99.2% amino acid sequence identity at the S gene level and 99.3% and 99.0%-99.6% nucleotide sequence homology at the genome level compared to the corresponding Korean prototype G1b and G2b strains, respectively. In an interesting manner, one G2b-like KNU-1705 strain was found to possess a large 39-nucleotide deletion in the ORF1a region theoretically encoding nonstructural protein 3. Phylogenetic analysis based on the entire genome and spike protein sequences indicated that the 2017 isolates were most closely related to other global G1b or G2b strains but formed different branches within the same genogroup. These results indicate that PEDVs undergo continuous evolution in the field. In addition, one 2017 PEDV strain, KOR/KNU-1705/2017, was successfully isolated and propagated in Vero cells. The antisera raised against the Korean prototype 2014 G2b strain efficiently neutralized KNU-1705 virus infection, suggesting antigenic homology between the 2014 and 2017 PEDV strains. Our data advance the understanding of the molecular epidemiology and antigenicity of PEDV circulating in South Korea. Twit Text FOAVip Genomic and antigenic characterization of porcine epidemic diarrhoea virus strains isolated from South Korea, 2017 ????Transbound Emerg Dis http://www.kidney.de/pget.php?&tw=1&pmid=29770590 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29770590 #FOAvip English Wikipedia <ref>{{Cite pmid|29770590}}</ref> Genomic and antigenic characterization of porcine epidemic diarrhoea virus strains isolated from South Korea, 2017 #MMPMID29770590 Lee S; Lee C Transbound Emerg Dis 2018[Aug]; 65 (4): 949-956 PMID29770590show ga Porcine epidemic diarrhoea virus (PEDV) is a globally emerging and re-emerging enteric coronavirus in pigs causing serious economic threats to the world swine industry. Since the re-emergence of massive PEDV outbreaks in South Korea in 2013-2014, domestic pig farms have continued to experience PED epidemics or endemics. This study represents the molecular characterization of PEDV isolates identified in diarrhoeic animals collected across the country in 2017. Initial sequencing analysis of the full-length S genes revealed that 70% of the 2017 isolates (7/10) belong to the G2b subgroup, while the remaining isolates were classified as G1b. The data indicated that both variant G1b and global epidemic G2b strains were responsible for current PED outbreaks in South Korea. The 2017 G1b and G2b isolates shared 98.7%-99.4% and 98.1%-99.2% amino acid sequence identity at the S gene level and 99.3% and 99.0%-99.6% nucleotide sequence homology at the genome level compared to the corresponding Korean prototype G1b and G2b strains, respectively. In an interesting manner, one G2b-like KNU-1705 strain was found to possess a large 39-nucleotide deletion in the ORF1a region theoretically encoding nonstructural protein 3. Phylogenetic analysis based on the entire genome and spike protein sequences indicated that the 2017 isolates were most closely related to other global G1b or G2b strains but formed different branches within the same genogroup. These results indicate that PEDVs undergo continuous evolution in the field. In addition, one 2017 PEDV strain, KOR/KNU-1705/2017, was successfully isolated and propagated in Vero cells. The antisera raised against the Korean prototype 2014 G2b strain efficiently neutralized KNU-1705 virus infection, suggesting antigenic homology between the 2014 and 2017 PEDV strains. Our data advance the understanding of the molecular epidemiology and antigenicity of PEDV circulating in South Korea. |Amino Acid Sequence[MESH] |Animals[MESH] |Chlorocebus aethiops[MESH] |Coronavirus Infections/epidemiology/*veterinary/virology[MESH] |Disease Outbreaks[MESH] |Genome, Viral[MESH] |Genomics[MESH] |Genotype[MESH] |Molecular Epidemiology[MESH] |Phylogeny[MESH] |Porcine epidemic diarrhea virus/*genetics/*immunology/isolation & purification[MESH] |Republic of Korea/epidemiology[MESH] |Sequence Homology[MESH] |Swine[MESH] |Swine Diseases/epidemiology/*virology[MESH]Genomic and antigenic characterization of porcine epidemic diarrhoea v(epmc).pdf DeepDyve Pubget Overpricing