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Immunomodulatory Function of Myeloid-Derived Suppressor Cells during B Cell-Mediated Immune Responses #MMPMID29762501
Ozkan B; Lim H; Park SG
Int J Mol Sci 2018[May]; 19 (5): ? PMID29762501show ga
Myeloid-derived suppressor cells (MDSCs) play roles in immune regulation during neoplastic and non-neoplastic inflammatory responses. This immune regulatory function is directed mainly toward T cells. However, MDSCs also regulate other cell populations, including B cells, during inflammatory responses. Indeed, B cells are essential for antibody-mediated immune responses. MDSCs regulate B cell immune responses directly via expression of effector molecules and indirectly by controlling other immune regulatory cells. B cell-mediated immune responses are a major component of the overall immune response; thus, MDSCs play a prominent role in their regulation. Here, we review the current knowledge about MDSC-mediated regulation of B cell responses.