Atrial natriuretic hormone has biological effects in man at physiological plasma concentrations #MMPMID2973471
Richards AM; McDonald D; Fitzpatrick MA; Nicholls MG; Espiner EA; Ikram H; Jans S; Grant S; Yandle T
J Clin Endocrinol Metab 1988[Dec]; 67 (6): 1134-9 PMID2973471show ga
Whether atrial natriuretic hormone (ANH) has biological effects at physiological plasma levels in man is not known. Accordingly, we investigated the effects of a 3-h low dose infusion of human ANF (0.75 pmol/kg.min; i.e. 0.0023 micrograms/kg.min) in six normal men, whose sodium intake was normal while sitting, in a single blind, random order, placebo-controlled study. The ANF infusions induced changes in plasma ANH concentrations entirely within the range for normal subjects. The small increases in plasma ANH values were associated with a significant rise in urinary excretion of sodium, magnesium, calcium, and cGMP. PRA and plasma aldosterone concentrations uniformly decreased to 50% and 64% of placebo values, respectively. Systolic and mean arterial pressures fell significantly from preinfusion values during the ANH infusions. These findings constitute strong evidence that ANH is a hormone of physiological significance in the regulation of body fluid volumes in normal man.
J+Clin+Endocrinol+Metab 1988 ; 67 (6): 1134-9
