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10.1093/nar/16.20.9811 http://scihub22266oqcxt.onion/10.1093/nar/16.20.9811 2972994!338780!2972994     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nucleic+Acids+Res 1988 ; 16 (20): 9811-20 Nephropedia Template TP {{tp|p=2972994|t=1988. Sequence specificity of streptozotocin-induced mutations |pdf=|usr=}}{{2972994}} gab.com Text Sequence specificity of streptozotocin-induced mutations JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=2972994 #FOAvip The isolation and characterization of streptozotocin (STZ)-induced mutations in the phage P22 mnt repressor gene is described. Cells carrying the plasmid-borne mnt gene were exposed to STZ to give 10-20 percent survival and at least an eleven-fold increase in mutation frequency. DNA sequence analysis showed that 50 of 51 STZ-induced mutations were GC to AT transitions, and one was an AT to GC transition. We have also compared the STZ mutational spectrum to that for N-methyl-N'-nitro-N-nitroso-guanidine (MNNG). There are sites in the mnt gene which are mutated only by STZ; only by MNNG, or by both agents. Sites at which only STZ induced GC to AT transition mutations occur were in sequences that are pyrimidine rich 5' to the mutated site and purine rich 3' to the mutated site. Induction of mutations by both STZ and MNNG should be considered to maximize the number of mutable sites. Twit Text FOAVip Sequence specificity of streptozotocin-induced mutations ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=2972994 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=2972994 #FOAvip English Wikipedia <ref>{{Cite pmid|2972994}}</ref> Sequence specificity of streptozotocin-induced mutations #MMPMID2972994 Mack SL; Fram RJ; Marinus MG Nucleic Acids Res 1988[Oct]; 16 (20): 9811-20 PMID2972994show ga The isolation and characterization of streptozotocin (STZ)-induced mutations in the phage P22 mnt repressor gene is described. Cells carrying the plasmid-borne mnt gene were exposed to STZ to give 10-20 percent survival and at least an eleven-fold increase in mutation frequency. DNA sequence analysis showed that 50 of 51 STZ-induced mutations were GC to AT transitions, and one was an AT to GC transition. We have also compared the STZ mutational spectrum to that for N-methyl-N'-nitro-N-nitroso-guanidine (MNNG). There are sites in the mnt gene which are mutated only by STZ; only by MNNG, or by both agents. Sites at which only STZ induced GC to AT transition mutations occur were in sequences that are pyrimidine rich 5' to the mutated site and purine rich 3' to the mutated site. Induction of mutations by both STZ and MNNG should be considered to maximize the number of mutable sites. |*Base Sequence/drug effects[MESH] |*DNA Mutational Analysis/methods[MESH] |*Mutation[MESH] |*Streptozocin[MESH] |Coliphages/drug effects/genetics[MESH] |Methylnitronitrosoguanidine[MESH]Sequence specificity of streptozotocin-induced mutations (epmc).pdf DeepDyve Pubget Overpricing