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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Adv+Healthc+Mater 2018 ; 7 (13): e1701400 Nephropedia Template TP
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Recent Advances in the Development of Antimicrobial Nanoparticles for Combating Resistant Pathogens #MMPMID29717819
Lakshminarayanan R; Ye E; Young DJ; Li Z; Loh XJ
Adv Healthc Mater 2018[Jul]; 7 (13): e1701400 PMID29717819show ga
The rapid growth of harmful pathogens and their multidrug-resistance poses a severe challenge for health professionals and for the development of new healthcare products. Various strategies are exploited for the development of effective antimicrobial agents, and nanoparticles are a particularly promising class of materials in this respect. This review summarizes recent advances in antimicrobial metallic, polymeric, and lipid-based nanoparticles such as liposomes, solid lipid nanoparticles, and nanostructured lipid carriers. The latter materials in particular are engineered for antimicrobial agent delivery and act by encapsulation, receptor-based binding, and disruption of microbial adherence to cellular substrates. Potential strategies for the design of multifunctional antimicrobial nanocarriers, combining material chemistry and biological interface science, are also discussed.