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10.1128/JVI.62.8.2884-2889.1988 http://scihub22266oqcxt.onion/10.1128/JVI.62.8.2884-2889.1988 2969055!253725!2969055     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=2969055&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Virol 1988 ; 62 (8): 2884-9 Nephropedia Template TP {{tp|p=2969055|t=1988. The gene encoding the nonstructural protein of B19 (human) parvovirus may be lethal in transfected cells |pdf=|usr=}}{{2969055}} gab.com Text The gene encoding the nonstructural protein of B19 (human) parvovirus may be lethal in transfected cells JO: J Virol http://www.kidney.de/pget.php?&tw=1&pmid=2969055 #FOAvip The B19 parvovirus is a cause of bone marrow failure in humans. B19 is toxic to erythroid progenitor cells in vitro. Viral products possibly responsible for toxicity were explored by transfection of cloned B19 genome into HeLa cells. The nonstructural (NS) protein was detected in cells 30 h after transfection. Plasmids containing the B19 genome were transfected with selectable marker genes in stable transformation assays. Plasmids that contained the left side of the B19 genome, which encodes the NS protein of the virus, inhibited antibiotic-resistant colony formation. Transformation occurred when NS protein expression was blocked by mutation. Suppression of transformation by NS protein was not tissue specific, suggesting a role for NS protein in toxicity for nonpermissive cells without parvovirus replication or virion accumulation. Twit Text FOAVip The gene encoding the nonstructural protein of B19 (human) parvovirus may be lethal in transfected cells ????J Virol http://www.kidney.de/pget.php?&tw=1&pmid=2969055 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=2969055 #FOAvip English Wikipedia <ref>{{Cite pmid|2969055}}</ref> The gene encoding the nonstructural protein of B19 (human) parvovirus may be lethal in transfected cells #MMPMID2969055 Ozawa K; Ayub J; Kajigaya S; Shimada T; Young N J Virol 1988[Aug]; 62 (8): 2884-9 PMID2969055show ga The B19 parvovirus is a cause of bone marrow failure in humans. B19 is toxic to erythroid progenitor cells in vitro. Viral products possibly responsible for toxicity were explored by transfection of cloned B19 genome into HeLa cells. The nonstructural (NS) protein was detected in cells 30 h after transfection. Plasmids containing the B19 genome were transfected with selectable marker genes in stable transformation assays. Plasmids that contained the left side of the B19 genome, which encodes the NS protein of the virus, inhibited antibiotic-resistant colony formation. Transformation occurred when NS protein expression was blocked by mutation. Suppression of transformation by NS protein was not tissue specific, suggesting a role for NS protein in toxicity for nonpermissive cells without parvovirus replication or virion accumulation. |*Genes, Lethal[MESH] |*Genes, Viral[MESH] |Capsid/*genetics[MESH] |Gene Expression Regulation[MESH] |Molecular Weight[MESH] |Parvoviridae/*genetics/pathogenicity[MESH] |Promoter Regions, Genetic[MESH] |Transcription, Genetic[MESH] |Transfection[MESH] |Transformation, Genetic[MESH] |Viral Core Proteins/*genetics[MESH]The gene encoding the nonstructural protein of B19 (human) parvovirus (epmc).pdf DeepDyve Pubget Overpricing