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10.1016/j.bbadis.2018.04.017 http://scihub22266oqcxt.onion/10.1016/j.bbadis.2018.04.017 29684587!ä!29684587 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Biophys+Acta+Mol+Basis+Dis 2018 ; 1864 (7): 2409-2419 Nephropedia Template TP {{tp|p=29684587|t=2018. TRPM7 controls mesenchymal features of breast cancer cells by tensional regulation of SOX4 |pdf=|usr=}}{{29684587}} gab.com Text TRPM7 controls mesenchymal features of breast cancer cells by tensional regulation of SOX4 JO: Biochim Biophys Acta Mol Basis Dis http://www.kidney.de/pget.php?&tw=1&pmid=29684587 #FOAvip Mechanically induced signaling pathways are important drivers of tumor progression. However, if and how mechanical signals affect metastasis or therapy response remains poorly understood. We previously found that the channel-kinase TRPM7, a regulator of cellular tension implicated in mechano-sensory processes, is required for breast cancer metastasis in vitro and in vivo. Here, we show that TRPM7 contributes to maintaining a mesenchymal phenotype in breast cancer cells by tensional regulation of the EMT transcription factor SOX4. The functional consequences of SOX4 knockdown closely mirror those produced by TRPM7 knockdown. By traction force measurements, we demonstrate that TRPM7 reduces cytoskeletal tension through inhibition of myosin II activity. Moreover, we show that SOX4 expression and downstream mesenchymal markers are inversely regulated by cytoskeletal tension and matrix rigidity. Overall, our results identify SOX4 as a transcription factor that is uniquely sensitive to cellular tension and indicate that TRPM7 may contribute to breast cancer progression by tensional regulation of SOX4. Twit Text FOAVip TRPM7 controls mesenchymal features of breast cancer cells by tensional regulation of SOX4 ????Biochim Biophys Acta Mol Basis Dis http://www.kidney.de/pget.php?&tw=1&pmid=29684587 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29684587 #FOAvip English Wikipedia <ref>{{Cite pmid|29684587}}</ref> TRPM7 controls mesenchymal features of breast cancer cells by tensional regulation of SOX4 #MMPMID29684587 Kuipers AJ; Middelbeek J; Vrenken K; Perez-Gonzalez C; Poelmans G; Klarenbeek J; Jalink K; Trepat X; van Leeuwen FN Biochim Biophys Acta Mol Basis Dis 2018[Jul]; 1864 (7): 2409-2419 PMID29684587show ga Mechanically induced signaling pathways are important drivers of tumor progression. However, if and how mechanical signals affect metastasis or therapy response remains poorly understood. We previously found that the channel-kinase TRPM7, a regulator of cellular tension implicated in mechano-sensory processes, is required for breast cancer metastasis in vitro and in vivo. Here, we show that TRPM7 contributes to maintaining a mesenchymal phenotype in breast cancer cells by tensional regulation of the EMT transcription factor SOX4. The functional consequences of SOX4 knockdown closely mirror those produced by TRPM7 knockdown. By traction force measurements, we demonstrate that TRPM7 reduces cytoskeletal tension through inhibition of myosin II activity. Moreover, we show that SOX4 expression and downstream mesenchymal markers are inversely regulated by cytoskeletal tension and matrix rigidity. Overall, our results identify SOX4 as a transcription factor that is uniquely sensitive to cellular tension and indicate that TRPM7 may contribute to breast cancer progression by tensional regulation of SOX4. |Breast Neoplasms/genetics/*metabolism/pathology[MESH] |Cell Line, Tumor[MESH] |Cytoskeleton/genetics/metabolism/pathology[MESH] |Female[MESH] |Gene Knockdown Techniques[MESH] |Humans[MESH] |Myosin Type II/genetics/metabolism[MESH] |Neoplasm Proteins/genetics/*metabolism[MESH] |Protein Serine-Threonine Kinases/genetics/*metabolism[MESH] |SOXC Transcription Factors/genetics/*metabolism[MESH] |TRPM Cation Channels/genetics/*metabolism[MESH]TRPM7 controls mesenchymal features of breast cancer cells by tensiona(epmc).pdf DeepDyve Pubget Overpricing