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10.1053/j.ackd.2017.12.005 http://scihub22266oqcxt.onion/10.1053/j.ackd.2017.12.005 29580581!5898826!29580581     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29580581&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Adv+Chronic+Kidney+Dis 2018 ; 25 (2): 166-180 Nephropedia Template TP {{tp|p=29580581|t=2018. Acute Kidney Injury and Progression of Diabetic Kidney Disease |pdf=|usr=}}{{29580581}} gab.com Text Acute Kidney Injury and Progression of Diabetic Kidney Disease JO: Adv Chronic Kidney Dis http://www.kidney.de/pget.php?&tw=1&pmid=29580581 #FOAvip Diabetic kidney disease, commonly termed diabetic nephropathy (DN), is the most common cause of end-stage kidney disease (ESKD) worldwide. The characteristic histopathology of DN includes glomerular basement membrane thickening, mesangial expansion, nodular glomerular sclerosis, and tubulointerstitial fibrosis. Diabetes is associated with a number of metabolic derangements, such as reactive oxygen species overproduction, hypoxic state, mitochondrial dysfunction, and inflammation. In the past few decades, our knowledge of DN has advanced considerably although much needs to be learned. The traditional paradigm of glomerulus-centered pathophysiology has expanded to the tubule-interstitium, the immune response and inflammation. Biomarkers of proximal tubule injury have been shown to correlate with DN progression, independent of traditional glomerular injury biomarkers such as albuminuria. In this review, we summarize mechanisms of increased susceptibility to acute kidney injury in diabetes mellitus and the roles played by many kidney cell types to facilitate maladaptive responses leading to chronic and end-stage kidney disease. Twit Text FOAVip Acute Kidney Injury and Progression of Diabetic Kidney Disease ????Adv Chronic Kidney Dis http://www.kidney.de/pget.php?&tw=1&pmid=29580581 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29580581 #FOAvip English Wikipedia <ref>{{Cite pmid|29580581}}</ref> Acute Kidney Injury and Progression of Diabetic Kidney Disease #MMPMID29580581 Yu SM; Bonventre JV Adv Chronic Kidney Dis 2018[Mar]; 25 (2): 166-180 PMID29580581show ga Diabetic kidney disease, commonly termed diabetic nephropathy (DN), is the most common cause of end-stage kidney disease (ESKD) worldwide. The characteristic histopathology of DN includes glomerular basement membrane thickening, mesangial expansion, nodular glomerular sclerosis, and tubulointerstitial fibrosis. Diabetes is associated with a number of metabolic derangements, such as reactive oxygen species overproduction, hypoxic state, mitochondrial dysfunction, and inflammation. In the past few decades, our knowledge of DN has advanced considerably although much needs to be learned. The traditional paradigm of glomerulus-centered pathophysiology has expanded to the tubule-interstitium, the immune response and inflammation. Biomarkers of proximal tubule injury have been shown to correlate with DN progression, independent of traditional glomerular injury biomarkers such as albuminuria. In this review, we summarize mechanisms of increased susceptibility to acute kidney injury in diabetes mellitus and the roles played by many kidney cell types to facilitate maladaptive responses leading to chronic and end-stage kidney disease. |*Acute Kidney Injury/etiology/metabolism[MESH] |*Diabetes Mellitus, Type 2/complications/metabolism[MESH] |*Diabetic Nephropathies/etiology/metabolism/physiopathology[MESH] |*Kidney Failure, Chronic/diagnosis/etiology/physiopathology[MESH] |Disease Progression[MESH]Acute Kidney Injury and Progression of Diabetic Kidney Disease (epmc).pdf DeepDyve Pubget Overpricing