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10.1007/s00018-018-2786-z http://scihub22266oqcxt.onion/10.1007/s00018-018-2786-z 29500477!6033657!29500477     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Life+Sci 2018 ; 75 (16): 3069-3078 Nephropedia Template TP {{tp|p=29500477|t=2018. The TRPM7 kinase limits receptor-induced calcium release by regulating heterotrimeric G-proteins |pdf=|usr=}}{{29500477}} gab.com Text The TRPM7 kinase limits receptor-induced calcium release by regulating heterotrimeric G-proteins JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=29500477 #FOAvip The melastatin-related transient receptor potential member 7 (TRPM7) is a unique fusion protein with both ion channel function and enzymatic alpha-kinase activity. TRPM7 is essential for cellular systemic magnesium homeostasis and early embryogenesis; it promotes calcium transport during global brain ischemia and emerges as a key player in cancer growth. TRPM7 channels are negatively regulated through G-protein-coupled receptor-stimulation, either by reducing cellular cyclic adenosine monophosphate (cAMP) or depleting phosphatidylinositol bisphosphate (PIP(2)) levels in the plasma membrane. We here identify that heterologous overexpression of human TRPM7-K1648R mutant will lead to disruption of protease or purinergic receptor-induced calcium release. The disruption occurs at the level of G(q), which requires intact TRPM7 kinase phosphorylation activity for orderly downstream signal transduction to activate phospholipase (PLC)beta and cause calcium release. We propose that this mechanism may support limiting GPCR-mediated calcium signaling in times of insufficient cellular ATP supply. Twit Text FOAVip The TRPM7 kinase limits receptor-induced calcium release by regulating heterotrimeric G-proteins ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=29500477 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29500477 #FOAvip English Wikipedia <ref>{{Cite pmid|29500477}}</ref> The TRPM7 kinase limits receptor-induced calcium release by regulating heterotrimeric G-proteins #MMPMID29500477 Suzuki S; Lis A; Schmitz C; Penner R; Fleig A Cell Mol Life Sci 2018[Aug]; 75 (16): 3069-3078 PMID29500477show ga The melastatin-related transient receptor potential member 7 (TRPM7) is a unique fusion protein with both ion channel function and enzymatic alpha-kinase activity. TRPM7 is essential for cellular systemic magnesium homeostasis and early embryogenesis; it promotes calcium transport during global brain ischemia and emerges as a key player in cancer growth. TRPM7 channels are negatively regulated through G-protein-coupled receptor-stimulation, either by reducing cellular cyclic adenosine monophosphate (cAMP) or depleting phosphatidylinositol bisphosphate (PIP(2)) levels in the plasma membrane. We here identify that heterologous overexpression of human TRPM7-K1648R mutant will lead to disruption of protease or purinergic receptor-induced calcium release. The disruption occurs at the level of G(q), which requires intact TRPM7 kinase phosphorylation activity for orderly downstream signal transduction to activate phospholipase (PLC)beta and cause calcium release. We propose that this mechanism may support limiting GPCR-mediated calcium signaling in times of insufficient cellular ATP supply. |Calcium/*metabolism[MESH] |Cyclic AMP/metabolism[MESH] |HEK293 Cells[MESH] |Heterotrimeric GTP-Binding Proteins/*metabolism[MESH] |Humans[MESH] |Intracellular Space/drug effects/metabolism[MESH] |Mutation, Missense[MESH] |Phosphorylation[MESH] |Protein Serine-Threonine Kinases/genetics/*metabolism[MESH] |Receptors, G-Protein-Coupled/*metabolism[MESH] |TRPM Cation Channels/genetics/*metabolism[MESH]The TRPM7 kinase limits receptor-induced calcium release by regulating(epmc).pdf DeepDyve Pubget Overpricing