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10.1080/08923973.2018.1441300 http://scihub22266oqcxt.onion/10.1080/08923973.2018.1441300 29486613!ä!29486613 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29486613&cmd=llinks): Failed to open stream: HTTP request failed! 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Magnesium isoglycyrrhizinate attenuates D-galactosamine/lipopolysaccharides induced acute liver injury of rat via regulation of the p38-MAPK and NF-kappaB signaling pathways |pdf=|usr=}}{{29486613}} gab.com Text Magnesium isoglycyrrhizinate attenuates D-galactosamine/lipopolysaccharides induced acute liver injury of rat via regulation of the p38-MAPK and NF-kappaB signaling pathways JO: Immunopharmacol Immunotoxicol http://www.kidney.de/pget.php?&tw=1&pmid=29486613 #FOAvip CONTEXT: Acute hepatic failure involves in serious inflammatory responses and leads to a high mortality. Magnesium isoglycyrrhizinate (MgIG), a magnesium salt of 18-alpha glycyrrhizic acid (GA) stereoisomer, has been shown anti-inflammatory activity previously. OBJECTIVE: This study aimed to investigate the protective effects of MgIG, a hepatocyte protective agent, on D-galactosamine and lipopolysaccharide (D-GaIN/LPS)-induced acute liver injury in rats, and meanwhile explore the molecular mechanism. MATERIALS AND METHODS: Male Sprague-Dawley (SD) rats were injected with D-GaIN/LPS (800 mg/kgBW/10 mug/kgBW) with or without administration of MgIG (225 mg/kg once 6 h after D-GaIN/LPS injection and MgIG 45 mg/kg twice in another 12 h, intraperitoneal injection). Rats were sacrificed 24 h after D-GaIN/LPS injection, the blood and liver samples were collected for future inflammation and hepatotoxicity analyses. RESULTS: MgIG significantly inhibited D-GaIN/LPS-induced inflammatory cytokines production and hepatotoxicity as indicated by both diagnostic indicators of liver damage [aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels] and histopathological analysis. Western blot analysis demonstrated that MgIG significantly decreased p38-mitogen activated protein kinase (MAPK) and nuclear factor kappa B (NF-kappaB) activation induced by D-GaIN/LPS. CONCLUSION: The results indicated that the protective effects of MgIG on D-GaIN/LPS-induced acute liver injury might be correlated with its capacity to regulate the p38-MAPK and NF-kappaB signaling pathways. Twit Text FOAVip Magnesium isoglycyrrhizinate attenuates D-galactosamine/lipopolysaccharides induced acute liver injury of rat via regulation of the p38-MAPK and NF-kappaB signaling pathways ????Immunopharmacol Immunotoxicol http://www.kidney.de/pget.php?&tw=1&pmid=29486613 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29486613 #FOAvip English Wikipedia <ref>{{Cite pmid|29486613}}</ref> Magnesium isoglycyrrhizinate attenuates D-galactosamine/lipopolysaccharides induced acute liver injury of rat via regulation of the p38-MAPK and NF-kappaB signaling pathways #MMPMID29486613 Wang W; Li X; Xu J Immunopharmacol Immunotoxicol 2018[Jun]; 40 (3): 262-267 PMID29486613show ga CONTEXT: Acute hepatic failure involves in serious inflammatory responses and leads to a high mortality. Magnesium isoglycyrrhizinate (MgIG), a magnesium salt of 18-alpha glycyrrhizic acid (GA) stereoisomer, has been shown anti-inflammatory activity previously. OBJECTIVE: This study aimed to investigate the protective effects of MgIG, a hepatocyte protective agent, on D-galactosamine and lipopolysaccharide (D-GaIN/LPS)-induced acute liver injury in rats, and meanwhile explore the molecular mechanism. MATERIALS AND METHODS: Male Sprague-Dawley (SD) rats were injected with D-GaIN/LPS (800 mg/kgBW/10 mug/kgBW) with or without administration of MgIG (225 mg/kg once 6 h after D-GaIN/LPS injection and MgIG 45 mg/kg twice in another 12 h, intraperitoneal injection). Rats were sacrificed 24 h after D-GaIN/LPS injection, the blood and liver samples were collected for future inflammation and hepatotoxicity analyses. RESULTS: MgIG significantly inhibited D-GaIN/LPS-induced inflammatory cytokines production and hepatotoxicity as indicated by both diagnostic indicators of liver damage [aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels] and histopathological analysis. Western blot analysis demonstrated that MgIG significantly decreased p38-mitogen activated protein kinase (MAPK) and nuclear factor kappa B (NF-kappaB) activation induced by D-GaIN/LPS. CONCLUSION: The results indicated that the protective effects of MgIG on D-GaIN/LPS-induced acute liver injury might be correlated with its capacity to regulate the p38-MAPK and NF-kappaB signaling pathways. |Animals[MESH] |Chemical and Drug Induced Liver Injury/*drug therapy/immunology/pathology[MESH] |Galactosamine/*toxicity[MESH] |Lipopolysaccharides/*toxicity[MESH] |MAP Kinase Signaling System/*drug effects/immunology[MESH] |Male[MESH] |NF-kappa B/*immunology[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH] |Saponins/*pharmacology[MESH] |Triterpenes/*pharmacology[MESH]Magnesium isoglycyrrhizinate attenuates D-galactosamine/lipopolysaccha(epmc).pdf DeepDyve Pubget Overpricing