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10.1016/j.neulet.2018.02.035 http://scihub22266oqcxt.onion/10.1016/j.neulet.2018.02.035 29474875!ä!29474875 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neurosci+Lett 2018 ; 672 (ä): 46-52 Nephropedia Template TP {{tp|p=29474875|t=2018. Rig-I is involved in inflammation through the IPS-1/TRAF(6) pathway in astrocytes under chemical hypoxia |pdf=|usr=}}{{29474875}} gab.com Text Rig-I is involved in inflammation through the IPS-1/TRAF(6) pathway in astrocytes under chemical hypoxia JO: Neurosci Lett http://www.kidney.de/pget.php?&tw=1&pmid=29474875 #FOAvip The retinoic acid-inducible gene I (RIG-I) is a crucial cytoplasmic pathogen recognition receptor involved in neuroinflammation in degenerative diseases. In the present study, in vitro human astrocytes were subjected to a chemical hypoxia model using cobalt chloride pretreatment. Chemical hypoxia induces the up-regulation of RIG-I in astrocytes and results in the expression of inflammatory cytokines IL-1beta, IL-6, and TNF-alpha in an NF-kappaB dependent manner. Elevated RIG-I modulates the interaction of interferon-beta promoter stimulator-1 (IPS-1) and TNF receptor-associated factor 6 (TRAF6) following chemical hypoxia. Inhibition of IPS-1 or TRAF6 suppresses RIG-I-induced NF-kappaB activation and inflammatory cytokines in response to chemical hypoxia. These data suggest that chemical hypoxia leads to RIG-I activation and the expression of inflammatory cytokines through the NF-kappaB pathway. Blocking IPS-1/TRAF6 pathway relieves RIG-I-induced neuroinflammation in astrocytes subjected to hypoxia. Twit Text FOAVip Rig-I is involved in inflammation through the IPS-1/TRAF(6) pathway in astrocytes under chemical hypoxia ????Neurosci Lett http://www.kidney.de/pget.php?&tw=1&pmid=29474875 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29474875 #FOAvip English Wikipedia <ref>{{Cite pmid|29474875}}</ref> Rig-I is involved in inflammation through the IPS-1/TRAF(6) pathway in astrocytes under chemical hypoxia #MMPMID29474875 Li L; Yang R; Feng M; Guo Y; Wang Y; Guo J; Lu X Neurosci Lett 2018[Apr]; 672 (ä): 46-52 PMID29474875show ga The retinoic acid-inducible gene I (RIG-I) is a crucial cytoplasmic pathogen recognition receptor involved in neuroinflammation in degenerative diseases. In the present study, in vitro human astrocytes were subjected to a chemical hypoxia model using cobalt chloride pretreatment. Chemical hypoxia induces the up-regulation of RIG-I in astrocytes and results in the expression of inflammatory cytokines IL-1beta, IL-6, and TNF-alpha in an NF-kappaB dependent manner. Elevated RIG-I modulates the interaction of interferon-beta promoter stimulator-1 (IPS-1) and TNF receptor-associated factor 6 (TRAF6) following chemical hypoxia. Inhibition of IPS-1 or TRAF6 suppresses RIG-I-induced NF-kappaB activation and inflammatory cytokines in response to chemical hypoxia. These data suggest that chemical hypoxia leads to RIG-I activation and the expression of inflammatory cytokines through the NF-kappaB pathway. Blocking IPS-1/TRAF6 pathway relieves RIG-I-induced neuroinflammation in astrocytes subjected to hypoxia. |Adaptor Proteins, Signal Transducing/*metabolism[MESH] |Astrocytes/drug effects/*metabolism[MESH] |Cell Hypoxia/drug effects/*physiology[MESH] |Cell Line, Tumor[MESH] |Cobalt/pharmacology[MESH] |DEAD Box Protein 58/*metabolism[MESH] |Humans[MESH] |Inflammation/metabolism[MESH] |Receptors, Immunologic[MESH] |Signal Transduction/drug effects[MESH] |TNF Receptor-Associated Factor 6/*metabolism[MESH]Rig-I is involved in inflammation through the IPS-1/TRAF(6) pathway in(epmc).pdf DeepDyve Pubget Overpricing