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Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Microb+Pathog 2018 ; 117 (ä): 27-31 Nephropedia Template TP
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Parvovirus B19 and in situ immune response in eczema and psoriasis skin lesions of patients from the Brazilian Amazon region #MMPMID29428424
Simoes ACL; de Souza Aarao TL; de Sousa JR; Prudente DL; de Castro YG; Maneschy RB; Fuzii HT; Quaresma JAS
Microb Pathog 2018[Apr]; 117 (ä): 27-31 PMID29428424show ga
Parvovirus B19 (PVB19) is a virus found in the skin that causes asymptomatic infections and can exist in the host for long periods to time. The virus induces a local inflammatory response and is associated with the development of arthritis and other autoimmunes diseases. Parvovirus B19 DNA was investigated by PCR in the skin of 20 patients with psoriasis and 20 patients with eczema. Additionally, immunohistochemistry was used to characterize the expression of cytokines in these lesions. The sociodemographic variables were similar in the two groups studied. Psoriasis vulgaris was the most common clinical type in men (50%) and women (80%) (p?=?0.0106). Comorbidities were observed in most patients with psoriasis (75%), with an OR of 14 (p?=?0.0068). Another important finding was the high prevalence (50%) of psychiatric disorders in patients with psoriasis (OR?=?16, p?=?0.0218). Only two patients (10%) with psoriasis were positive for PVB19. Comparison of cytokine expression showed the same cytokine profile in the two groups (p?>?0.05). However, expression of TNF-alpha tended to be higher in psoriasis patients. There was no significant positivity for PVB19 in the two groups studied. Immunohistochemistry showed higher expression of TNF-alpha in psoriasis lesions compared to the eczema group.