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10.1007/s00701-018-3467-2 http://scihub22266oqcxt.onion/10.1007/s00701-018-3467-2 29356895/?report=reader!5807463!29356895     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Neurochir+(Wien) 2018 ; 160 (3): 487-496 Nephropedia Template TP {{tp|p=29356895|t=2018. Management of spinal infection: a review of the literature |pdf=|usr=}}{{29356895}} gab.com Text Management of spinal infection: a review of the literature JO: Acta Neurochir (Wien) http://www.kidney.de/pget.php?&tw=1&pmid=29356895 #FOAvip Spinal infection (SI) is defined as an infectious disease affecting the vertebral body, the intervertebral disc, and/or adjacent paraspinal tissue and represents 2-7% of all musculoskeletal infections. There are numerous factors, which may facilitate the development of SI including not only advanced patient age and comorbidities but also spinal surgery. Due to the low specificity of signs, the delay in diagnosis of SI remains an important issue and poor outcome is frequently seen. Diagnosis should always be supported by clinical, laboratory, and imaging findings, magnetic resonance imaging (MRI) remaining the most reliable method. Management of SI depends on the location of the infection (i.e., intraspinal, intervertebral, paraspinal), on the disease progression, and of course on the patient's general condition, considering age and comorbidities. Conservative treatment mostly is reasonable in early stages with no or minor neurologic deficits and in case of severe comorbidities, which limit surgical options. Nevertheless, solely medical treatment often fails. Therefore, in case of doubt, surgical treatment should be considered. The final result in conservative as well as in surgical treatment always is bony fusion. Furthermore, both options require a concomitant antimicrobial therapy, initially applied intravenously and administered orally thereafter. The optimal duration of antibiotic therapy remains controversial, but should never undercut 6 weeks. Due to a heterogeneous and often comorbid patient population and the wide variety of treatment options, no generally applicable guidelines for SI exist and management remains a challenge. Thus, future prospective randomized trials are necessary to substantiate treatment strategies. Twit Text FOAVip Management of spinal infection: a review of the literature ????Acta Neurochir (Wien) http://www.kidney.de/pget.php?&tw=1&pmid=29356895 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29356895 #FOAvip English Wikipedia <ref>{{Cite pmid|29356895}}</ref> Management of spinal infection: a review of the literature #MMPMID29356895 Lener S; Hartmann S; Barbagallo GMV; Certo F; Thome C; Tschugg A Acta Neurochir (Wien) 2018[Mar]; 160 (3): 487-496 PMID29356895show ga Spinal infection (SI) is defined as an infectious disease affecting the vertebral body, the intervertebral disc, and/or adjacent paraspinal tissue and represents 2-7% of all musculoskeletal infections. There are numerous factors, which may facilitate the development of SI including not only advanced patient age and comorbidities but also spinal surgery. Due to the low specificity of signs, the delay in diagnosis of SI remains an important issue and poor outcome is frequently seen. Diagnosis should always be supported by clinical, laboratory, and imaging findings, magnetic resonance imaging (MRI) remaining the most reliable method. Management of SI depends on the location of the infection (i.e., intraspinal, intervertebral, paraspinal), on the disease progression, and of course on the patient's general condition, considering age and comorbidities. Conservative treatment mostly is reasonable in early stages with no or minor neurologic deficits and in case of severe comorbidities, which limit surgical options. Nevertheless, solely medical treatment often fails. Therefore, in case of doubt, surgical treatment should be considered. The final result in conservative as well as in surgical treatment always is bony fusion. Furthermore, both options require a concomitant antimicrobial therapy, initially applied intravenously and administered orally thereafter. The optimal duration of antibiotic therapy remains controversial, but should never undercut 6 weeks. Due to a heterogeneous and often comorbid patient population and the wide variety of treatment options, no generally applicable guidelines for SI exist and management remains a challenge. Thus, future prospective randomized trials are necessary to substantiate treatment strategies. |Anti-Bacterial Agents/therapeutic use[MESH] |Central Nervous System Infections/diagnostic imaging/drug therapy/microbiology/*therapy[MESH] |Humans[MESH] |Magnetic Resonance Imaging[MESH]Management of spinal infection: a review of the literature (epmc).pdf DeepDyve Pubget Overpricing