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Species-specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adults #MMPMID29350887
Bouvier M; Chen WJ; Arnold JC; Fairchok MP; Danaher PJ; Lalani T; Malone L; Mor D; Ridore M; Burgess TH; Millar EV
Influenza Other Respir Viruses 2018[Mar]; 12 (2): 299-303 PMID29350887show ga
Human coronavirus (HCoV) is a known cause of influenza-like illness (ILI). In a multisite, observational, longitudinal study of ILI among otherwise healthy adolescents and adults, 12% of subjects were PCR-positive for HCoV. The distribution of species was as follows: HCoV-OC43 (34%), HCoV-229E (28%), HCoV-NL63 (22%), and HCoV-HKU1 (16%). We did not observe species-specific differences in the clinical characteristics of HCoV infection, with the exception of HCoV-HKU1, for which the severity of gastrointestinal symptoms trended higher on the fourth day of illness.