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10.1002/JLB.4AB0517-184R http://scihub22266oqcxt.onion/10.1002/JLB.4AB0517-184R 29345359!ä!29345359 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29345359&cmd=llinks): Failed to open stream: HTTP request failed! 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PDZ proteins are expressed and regulated in antigen-presenting cells and are targets of influenza A virus |pdf=|usr=}}{{29345359}} gab.com Text PDZ proteins are expressed and regulated in antigen-presenting cells and are targets of influenza A virus JO: J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=29345359 #FOAvip In this work, we identified the expression, regulation, and viral targeting of Scribble and Dlg1 in antigen-presenting cells. Scribble and Dlg1 belong to the family of PDZ (postsynaptic density (PSD95), disc large (Dlg), and zonula occludens (ZO-1)) proteins involved in cell polarity. The relevance of PDZ proteins in cellular functions is reinforced by the fact that many viruses interfere with host PDZ-dependent interactions affecting cellular mechanisms thus favoring viral replication. The functions of Scribble and Dlg have been widely studied in polarized cells such as epithelial and neuron cells. However, within the cells of the immune system, their functions have been described only in T and B lymphocytes. Here we demonstrated that Scribble and Dlg1 are differentially expressed during antigen-presenting cell differentiation and dendritic cell maturation. While both Scribble and Dlg1 seem to participate in distinct dendritic cell functions, both are targeted by the viral protein NS1 of influenza A in a PDZ-dependent manner in dendritic cells. Our findings suggest that these proteins might be involved in the mechanisms of innate immunity and/or antigen processing and presentation that can be hijacked by viral pathogens. Twit Text FOAVip PDZ proteins are expressed and regulated in antigen-presenting cells and are targets of influenza A virus ????J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=29345359 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29345359 #FOAvip English Wikipedia <ref>{{Cite pmid|29345359}}</ref> PDZ proteins are expressed and regulated in antigen-presenting cells and are targets of influenza A virus #MMPMID29345359 Barreda D; Sanchez-Galindo M; Lopez-Flores J; Nava-Castro KE; Bobadilla K; Salgado-Aguayo A; Santos-Mendoza T J Leukoc Biol 2018[Apr]; 103 (4): 731-738 PMID29345359show ga In this work, we identified the expression, regulation, and viral targeting of Scribble and Dlg1 in antigen-presenting cells. Scribble and Dlg1 belong to the family of PDZ (postsynaptic density (PSD95), disc large (Dlg), and zonula occludens (ZO-1)) proteins involved in cell polarity. The relevance of PDZ proteins in cellular functions is reinforced by the fact that many viruses interfere with host PDZ-dependent interactions affecting cellular mechanisms thus favoring viral replication. The functions of Scribble and Dlg have been widely studied in polarized cells such as epithelial and neuron cells. However, within the cells of the immune system, their functions have been described only in T and B lymphocytes. Here we demonstrated that Scribble and Dlg1 are differentially expressed during antigen-presenting cell differentiation and dendritic cell maturation. While both Scribble and Dlg1 seem to participate in distinct dendritic cell functions, both are targeted by the viral protein NS1 of influenza A in a PDZ-dependent manner in dendritic cells. Our findings suggest that these proteins might be involved in the mechanisms of innate immunity and/or antigen processing and presentation that can be hijacked by viral pathogens. |*Host-Pathogen Interactions[MESH] |Adaptor Proteins, Signal Transducing/genetics/*metabolism[MESH] |Antigen-Presenting Cells/*immunology/metabolism/virology[MESH] |Dendritic Cells/immunology/metabolism/virology[MESH] |Discs Large Homolog 1 Protein[MESH] |Humans[MESH] |Influenza A virus/*pathogenicity[MESH] |Influenza, Human/immunology/metabolism/*virology[MESH] |Macrophages/immunology/metabolism/virology[MESH] |Membrane Proteins/genetics/*metabolism[MESH] |Monocytes/immunology/metabolism/virology[MESH] |PDZ Domains[MESH] |Tumor Suppressor Proteins/genetics/*metabolism[MESH]PDZ proteins are expressed and regulated in antigen-presenting cells a(epmc).pdf DeepDyve Pubget Overpricing