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10.1016/j.immuni.2017.11.026 http://scihub22266oqcxt.onion/10.1016/j.immuni.2017.11.026 29343440!5783319!29343440     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2018 ; 48 (1): 59-74.e5 Nephropedia Template TP {{tp|p=29343440|t=2018. Chanzyme TRPM7 Mediates the Ca(2+) Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation |pdf=|usr=}}{{29343440}} gab.com Text Chanzyme TRPM7 Mediates the Ca(2+) Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=29343440 #FOAvip Toll-like receptors (TLRs) sense pathogen-associated molecular patterns to activate the production of inflammatory mediators. TLR4 recognizes lipopolysaccharide (LPS) and drives the secretion of inflammatory cytokines, often contributing to sepsis. We report that transient receptor potential melastatin-like 7 (TRPM7), a non-selective but Ca(2+)-conducting ion channel, mediates the cytosolic Ca(2+) elevations essential for LPS-induced macrophage activation. LPS triggered TRPM7-dependent Ca(2+) elevations essential for TLR4 endocytosis and the subsequent activation of the transcription factor IRF3. In a parallel pathway, the Ca(2+) signaling initiated by TRPM7 was also essential for the nuclear translocation of NFkappaB. Consequently, TRPM7-deficient macrophages exhibited major deficits in the LPS-induced transcriptional programs in that they failed to produce IL-1beta and other key pro-inflammatory cytokines. In accord with these defects, mice with myeloid-specific deletion of Trpm7 are protected from LPS-induced peritonitis. Our study highlights the importance of Ca(2+) signaling in macrophage activation and identifies the ion channel TRPM7 as a central component of TLR4 signaling. Twit Text FOAVip Chanzyme TRPM7 Mediates the Ca(2+) Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=29343440 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29343440 #FOAvip English Wikipedia <ref>{{Cite pmid|29343440}}</ref> Chanzyme TRPM7 Mediates the Ca(2+) Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation #MMPMID29343440 Schappe MS; Szteyn K; Stremska ME; Mendu SK; Downs TK; Seegren PV; Mahoney MA; Dixit S; Krupa JK; Stipes EJ; Rogers JS; Adamson SE; Leitinger N; Desai BN Immunity 2018[Jan]; 48 (1): 59-74.e5 PMID29343440show ga Toll-like receptors (TLRs) sense pathogen-associated molecular patterns to activate the production of inflammatory mediators. TLR4 recognizes lipopolysaccharide (LPS) and drives the secretion of inflammatory cytokines, often contributing to sepsis. We report that transient receptor potential melastatin-like 7 (TRPM7), a non-selective but Ca(2+)-conducting ion channel, mediates the cytosolic Ca(2+) elevations essential for LPS-induced macrophage activation. LPS triggered TRPM7-dependent Ca(2+) elevations essential for TLR4 endocytosis and the subsequent activation of the transcription factor IRF3. In a parallel pathway, the Ca(2+) signaling initiated by TRPM7 was also essential for the nuclear translocation of NFkappaB. Consequently, TRPM7-deficient macrophages exhibited major deficits in the LPS-induced transcriptional programs in that they failed to produce IL-1beta and other key pro-inflammatory cytokines. In accord with these defects, mice with myeloid-specific deletion of Trpm7 are protected from LPS-induced peritonitis. Our study highlights the importance of Ca(2+) signaling in macrophage activation and identifies the ion channel TRPM7 as a central component of TLR4 signaling. |Animals[MESH] |Calcium/*metabolism[MESH] |Cell Culture Techniques[MESH] |Endocytosis/drug effects[MESH] |Female[MESH] |Flow Cytometry[MESH] |Fluorescent Antibody Technique[MESH] |Gene Expression Regulation[MESH] |Genotyping Techniques[MESH] |Immunoblotting[MESH] |Interferon Regulatory Factor-3/metabolism[MESH] |Lipopolysaccharides/pharmacology[MESH] |Macrophage Activation/*drug effects[MESH] |Macrophages/metabolism[MESH] |Male[MESH] |Mice[MESH] |NF-kappa B/metabolism[MESH] |Patch-Clamp Techniques[MESH] |Real-Time Polymerase Chain Reaction[MESH] |Signal Transduction/drug effects/physiology[MESH] |TRPM Cation Channels/genetics/*metabolism[MESH]Chanzyme TRPM7 Mediates the Ca(2+) Influx Essential for Lipopolysacch(epmc).pdf DeepDyve Pubget Overpricing