Myeloid-Derived Suppressor Cells Mediate Inflammation Resolution in Humans and Mice with Autoimmune Uveoretinitis #MMPMID29311360
Jeong HJ; Lee HJ; Ko JH; Cho BJ; Park SY; Park JW; Choi SR; Heo JW; Yoon SO; Oh JY
J Immunol 2018[Feb]; 200 (4): 1306-1315 PMID29311360show ga
Resolution of inflammation is an active process that leads to tissue homeostasis and involves multiple cellular and molecular mechanisms. Myeloid-derived suppressor cells (MDSCs) have recently emerged as important cellular components in the resolution of inflammation because of their activities to suppress T cell activation. In this article, we show that HLA-DR(-)CD11b(+)CD33(+)CD14(+) human MDSCs and CD11b(+)Ly6G(-)Ly6C(+) mouse MDSCs markedly increased in patients and mice during and before the resolution phase of autoimmune uveoretinitis. CD11b(+)Ly6C(+) monocytes isolated from autoimmune uveoretinitis mice were able to suppress T cell proliferation in culture, and adoptive transfer of the cells accelerated the remission of autoimmune uveoretinitis in mice. Alternatively, depletion of CD11b(+)Ly6C(+) monocytes at the resolution phase, but not CD11b(+)Ly6G(+) granulocytes, exacerbated the disease. These findings collectively indicate that monocytic MDSCs serve as regulatory cells mediating the resolution of autoimmune uveoretinitis.
J+Immunol 2018 ; 200 (4): 1306-1315
