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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Rev+Infect+Dis 1989 ; 11 Suppl 1 (ä): S145-49; discussion S149-50 Nephropedia Template TP
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Effect of trace metals on the synthesis of toxic shock syndrome toxin 1 #MMPMID2928630
The effect of 10 trace metals on the production of toxic shock syndrome toxin 1 (TSST-1) was studied in a metal-deficient chemically defined medium (CDM) with toxic shock syndrome (TSS) and non-TSS strains of Staphylococcus aureus. When individual metals were tested, only Mg++ stimulated cell growth and TSST-1 production. TSST-1 yield was responsive to the concentration of Mg++ in the medium, with a maximal yield occurring at 0.1 mM. When other metals were studied in the presence of Mg++ with and without 1 mM ethylenediamine tetraacetic acid, it was found that Ca++, Co++, Cu++, Fe++, Mn++, molybdate-, Ni++, vanadate-, and Zn++ produced some stimulation of either cell growth or TSST-1 synthesis or both. The stimulating effect of Mg++ on TSST-1 synthesis was significantly enhanced by adding 0.3 mM Zn++ and 0.003 mM Fe++. TSST-1 production by 11 strains of S. aureus in CDM with optimal concentrations of trace metals was two to seven times greater than that produced in brain-heart infusion broth.
Rev+Infect+Dis 1989 ; 11 Suppl 1 (ä): S145-49; discussion S149-50
