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10.1016/j.intimp.2017.12.019 http://scihub22266oqcxt.onion/10.1016/j.intimp.2017.12.019 29274625!ä!29274625 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29274625&cmd=llinks): Failed to open stream: HTTP request failed! 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Inhibition of myocardial hypertrophy by magnesium isoglycyrrhizinate through the TLR4/NF-kappaB signaling pathway in mice |pdf=|usr=}}{{29274625}} gab.com Text Inhibition of myocardial hypertrophy by magnesium isoglycyrrhizinate through the TLR4/NF-kappaB signaling pathway in mice JO: Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=29274625 #FOAvip Magnesium isoglycyrrhizinate (MgIG) is a magnesium salt of the 18-alpha glycyrrhizic acid stereoisomer that has exhibited hepato-protective effects and has anti-inflammatory, antioxidant, and antiviral activities. Here, we have investigated the effects and potential mechanisms of action of MgIG, with respect to myocardial fibrosis induced by isoproterenol (ISO) in mice. Mice were administered MgIG for 14days, with concurrent ISO dosing, and were sacrificed two weeks later. Lactate dehydrogenase (LDH) and creatine kinase (CK) concentrations were measured in the blood. Pathological changes in the myocardium were observed via light microscopy. In addition, the expression of the Bax and Bcl-2 genes, and the basic fibroblast growth factor (bFGF) protein were measured via an immunohistochemical method. The RNA expression of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), c-fos, and c-jun mRNA were quantified by reverse transcription-polymerase chain reaction (RT-PCR) in the myocardial tissue. The protein expression of toll-like receptor (TLR) 4, and nuclear factor kappa B (NF-kappaB) (p65) were measured using Western blot assays. Compared with the control group, the ISO group showed significant increases in bFGF, Bax, Bcl-2, TLR4, and NF-kappaB (p65) expressions, as well as increased serum levels of LDH and CK. MgIG had a protective effect on ISO-induced myocardial fibrosis, which might be ascribed, at least in part, to the inhibition of the TLR4/NF-kappaB (p65) signaling pathway. Twit Text FOAVip Inhibition of myocardial hypertrophy by magnesium isoglycyrrhizinate through the TLR4/NF-kappaB signaling pathway in mice ????Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=29274625 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29274625 #FOAvip English Wikipedia <ref>{{Cite pmid|29274625}}</ref> Inhibition of myocardial hypertrophy by magnesium isoglycyrrhizinate through the TLR4/NF-kappaB signaling pathway in mice #MMPMID29274625 Ma D; Zhang J; Zhang Y; Zhang X; Han X; Song T; Zhang Y; Chu L Int Immunopharmacol 2018[Feb]; 55 (ä): 237-244 PMID29274625show ga Magnesium isoglycyrrhizinate (MgIG) is a magnesium salt of the 18-alpha glycyrrhizic acid stereoisomer that has exhibited hepato-protective effects and has anti-inflammatory, antioxidant, and antiviral activities. Here, we have investigated the effects and potential mechanisms of action of MgIG, with respect to myocardial fibrosis induced by isoproterenol (ISO) in mice. Mice were administered MgIG for 14days, with concurrent ISO dosing, and were sacrificed two weeks later. Lactate dehydrogenase (LDH) and creatine kinase (CK) concentrations were measured in the blood. Pathological changes in the myocardium were observed via light microscopy. In addition, the expression of the Bax and Bcl-2 genes, and the basic fibroblast growth factor (bFGF) protein were measured via an immunohistochemical method. The RNA expression of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), c-fos, and c-jun mRNA were quantified by reverse transcription-polymerase chain reaction (RT-PCR) in the myocardial tissue. The protein expression of toll-like receptor (TLR) 4, and nuclear factor kappa B (NF-kappaB) (p65) were measured using Western blot assays. Compared with the control group, the ISO group showed significant increases in bFGF, Bax, Bcl-2, TLR4, and NF-kappaB (p65) expressions, as well as increased serum levels of LDH and CK. MgIG had a protective effect on ISO-induced myocardial fibrosis, which might be ascribed, at least in part, to the inhibition of the TLR4/NF-kappaB (p65) signaling pathway. |Animals[MESH] |Anti-Inflammatory Agents/*therapeutic use[MESH] |Atrial Natriuretic Factor/genetics/metabolism[MESH] |Creatine Kinase/blood[MESH] |Disease Models, Animal[MESH] |Fibroblast Growth Factor 2/metabolism[MESH] |Fibrosis[MESH] |Heart Diseases/*drug therapy[MESH] |Humans[MESH] |Hypertrophy[MESH] |Isoproterenol/administration & dosage[MESH] |L-Lactate Dehydrogenase/blood[MESH] |Mice[MESH] |Mice, Inbred Strains[MESH] |Myocardium/*pathology[MESH] |NF-kappa B/metabolism[MESH] |Natriuretic Peptide, Brain/genetics/metabolism[MESH] |Proto-Oncogene Proteins c-bcl-2/metabolism[MESH] |Saponins/*therapeutic use[MESH] |Toll-Like Receptor 4/metabolism[MESH] |Triterpenes/*therapeutic use[MESH]Inhibition of myocardial hypertrophy by magnesium isoglycyrrhizinate t(epmc).pdf DeepDyve Pubget Overpricing