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10.1097/MD.0000000000009071

http://scihub22266oqcxt.onion/10.1097/MD.0000000000009071
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suck abstract from ncbi


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pmid29245320      Medicine+(Baltimore) 2017 ; 96 (49): e9071
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  • QTc prolongation and torsades de pointes due to a coadministration of fluoxetine and amiodarone in a patient with implantable cardioverter-defibrillator: Case report and review of the literature #MMPMID29245320
  • Wei A; Peng J; Gu Z; Li J
  • Medicine (Baltimore) 2017[Dec]; 96 (49): e9071 PMID29245320show ga
  • RATIONALE: Drug-induced prolongation of the corrected QT interval (QTc) may lead to serious and potentially life-threatening ventricular tachyarrhythmia, such as torsades de pointes (Tdp), which is worthy of clinical attention. Here, we report 1 case of Tdp after a coadministration of fluoxetine and amiodarone. PATIENT CONCERNS: A 62-year-old Chinese male who placed with the implanted cardioverter-defibrillator (ICD) appeared the QTc prolongation and Tdp after the concurrent administration of fluoxetine and amiodarone. DIAGNOSES: Torsades de pointes (Tdp). INTERVENTIONS: The patient was treated with magnesium and potassium immediately. Her ICD-brady pacing mode was reprogrammed to 90 bpm. Meanwhile, both of fluoxetine and amiodarone were discontinued. OUTCOMES: The further episodes of Tdp were prevented. After a few days, the QTc gradually decreased without clinically significant arrhythmias. LESSONS: The present case demonstrates that a potential drug-drug interaction (DDI) may lead to a life-threatening drug adverse reaction (ADR) especially in special subjects. Therefore, clinicians should closely monitor the electrocardiogram (ECG) when QTc-prolonging agents are given to patients with cardiac abnormalities, and avoid combining 2 QTc-prolonging drugs.
  • |*Defibrillators, Implantable[MESH]
  • |*Drug Interactions[MESH]
  • |Amiodarone/administration & dosage/*adverse effects[MESH]
  • |Anti-Arrhythmia Agents/administration & dosage/*adverse effects[MESH]
  • |Cardiomyopathy, Dilated/*therapy[MESH]
  • |Electrocardiography[MESH]
  • |Fluoxetine/administration & dosage/*adverse effects[MESH]
  • |Humans[MESH]
  • |Long QT Syndrome/*chemically induced[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Selective Serotonin Reuptake Inhibitors/administration & dosage/*adverse effects[MESH]


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