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10.1111/ina.12445

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29244221!7165818!29244221
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suck abstract from ncbi


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pmid29244221      Indoor+Air 2018 ; 28 (3): 394-403
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  • Routes of transmission of influenza A H1N1, SARS CoV, and norovirus in air cabin: Comparative analyses #MMPMID29244221
  • Lei H; Li Y; Xiao S; Lin CH; Norris SL; Wei D; Hu Z; Ji S
  • Indoor Air 2018[May]; 28 (3): 394-403 PMID29244221show ga
  • Identifying the exact transmission route(s) of infectious diseases in indoor environments is a crucial step in developing effective intervention strategies. In this study, we proposed a comparative analysis approach and built a model to simulate outbreaks of 3 different in-flight infections in a similar cabin environment, that is, influenza A H1N1, severe acute respiratory syndrome (SARS) coronavirus (CoV), and norovirus. The simulation results seemed to suggest that the close contact route was probably the most significant route (contributes 70%, 95% confidence interval [CI]: 67%-72%) in the in-flight transmission of influenza A H1N1 transmission; as a result, passengers within 2 rows of the index case had a significantly higher infection risk than others in the outbreak (relative risk [RR]: 13.4, 95% CI: 1.5-121.2, P = .019). For SARS CoV, the airborne, close contact, and fomite routes contributed 21% (95% CI: 19%-23%), 29% (95% CI: 27%-31%), and 50% (95% CI: 48%-53%), respectively. For norovirus, the simulation results suggested that the fomite route played the dominant role (contributes 85%, 95% CI: 83%-87%) in most cases; as a result, passengers in aisle seats had a significantly higher infection risk than others (RR: 9.5, 95% CI: 1.2-77.4, P = .022). This work highlighted a method for using observed outbreak data to analyze the roles of different infection transmission routes.
  • |*Aircraft[MESH]
  • |*Computer Simulation[MESH]
  • |Air Pollution, Indoor/analysis[MESH]
  • |Caliciviridae Infections/*transmission[MESH]
  • |Disease Outbreaks[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Influenza A Virus, H1N1 Subtype[MESH]
  • |Influenza, Human/*transmission[MESH]
  • |Male[MESH]
  • |Norovirus[MESH]
  • |Risk[MESH]
  • |Severe Acute Respiratory Syndrome/*transmission[MESH]


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