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Biology of Bone Sarcomas and New Therapeutic Developments #MMPMID29238848
Brown HK; Schiavone K; Gouin F; Heymann MF; Heymann D
Calcif Tissue Int 2018[Feb]; 102 (2): 174-195 PMID29238848show ga
Bone sarcomas are tumours belonging to the family of mesenchymal tumours and constitute a highly heterogeneous tumour group. The three main bone sarcomas are osteosarcoma, Ewing sarcoma and chondrosarcoma each subdivided in diverse histological entities. They are clinically characterised by a relatively high morbidity and mortality, especially in children and adolescents. Although these tumours are histologically, molecularly and genetically heterogeneous, they share a common involvement of the local microenvironment in their pathogenesis. This review gives a brief overview of their specificities and summarises the main therapeutic advances in the field of bone sarcoma.