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10.1007/s00424-017-2085-9 http://scihub22266oqcxt.onion/10.1007/s00424-017-2085-9 29164310!5942358!29164310     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29164310&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Pflugers+Arch 2018 ; 470 (5): 779-786 Nephropedia Template TP {{tp|p=29164310|t=2018. Relevance of TRPA1 and TRPM8 channels as vascular sensors of cold in the cutaneous microvasculature |pdf=|usr=}}{{29164310}} gab.com Text Relevance of TRPA1 and TRPM8 channels as vascular sensors of cold in the cutaneous microvasculature JO: Pflugers Arch http://www.kidney.de/pget.php?&tw=1&pmid=29164310 #FOAvip Cold exposure is directly related to skin conditions, such as frostbite. This is due to the cold exposure inducing a vasoconstriction to reduce cutaneous blood flow and protect against heat loss. However, a long-term constriction will cause ischaemia and potentially irreversible damage. We have developed techniques to elucidate the mechanisms of the vascular cold response. We focused on two ligand-gated transient receptor potential (TRP) channels, namely, the established "cold sensors" TRP ankyrin 1 (TRPA1) and TRP melastin (TRPM8). We used the anaesthetised mouse and measured cutaneous blood flow by laser speckle imaging. Two cold treatments were used. A generalised cold treatment was achieved through whole paw water immersion (10 degrees C for 5 min) and a localised cold treatment that will be potentially easier to translate to human studies was carried out on the mouse paw with a copper cold probe (0.85-cm diameter). The results show that TRPA1 and TRPM8 can each act as a vascular cold sensor to mediate the vasoconstrictor component of whole paw cooling as expected from our previous research. However, the local cooling-induced responses were only blocked when the TRPA1 and TRPM8 antagonists were given simultaneously. This suggests that this localised cold probe response requires both functional TRPA1 and TRPM8. Twit Text FOAVip Relevance of TRPA1 and TRPM8 channels as vascular sensors of cold in the cutaneous microvasculature ????Pflugers Arch http://www.kidney.de/pget.php?&tw=1&pmid=29164310 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29164310 #FOAvip English Wikipedia <ref>{{Cite pmid|29164310}}</ref> Relevance of TRPA1 and TRPM8 channels as vascular sensors of cold in the cutaneous microvasculature #MMPMID29164310 Pan Y; Thapa D; Baldissera L Jr; Argunhan F; Aubdool AA; Brain SD Pflugers Arch 2018[May]; 470 (5): 779-786 PMID29164310show ga Cold exposure is directly related to skin conditions, such as frostbite. This is due to the cold exposure inducing a vasoconstriction to reduce cutaneous blood flow and protect against heat loss. However, a long-term constriction will cause ischaemia and potentially irreversible damage. We have developed techniques to elucidate the mechanisms of the vascular cold response. We focused on two ligand-gated transient receptor potential (TRP) channels, namely, the established "cold sensors" TRP ankyrin 1 (TRPA1) and TRP melastin (TRPM8). We used the anaesthetised mouse and measured cutaneous blood flow by laser speckle imaging. Two cold treatments were used. A generalised cold treatment was achieved through whole paw water immersion (10 degrees C for 5 min) and a localised cold treatment that will be potentially easier to translate to human studies was carried out on the mouse paw with a copper cold probe (0.85-cm diameter). The results show that TRPA1 and TRPM8 can each act as a vascular cold sensor to mediate the vasoconstrictor component of whole paw cooling as expected from our previous research. However, the local cooling-induced responses were only blocked when the TRPA1 and TRPM8 antagonists were given simultaneously. This suggests that this localised cold probe response requires both functional TRPA1 and TRPM8. |*Thermosensing[MESH] |Animals[MESH] |Cold Temperature[MESH] |Male[MESH] |Mice[MESH] |Microvessels/*metabolism/physiology[MESH] |Skin/*blood supply[MESH] |TRPA1 Cation Channel/*metabolism[MESH] |TRPM Cation Channels/*metabolism[MESH]Relevance of TRPA1 and TRPM8 channels as vascular sensors of cold in t(epmc).pdf DeepDyve Pubget Overpricing