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10.1016/j.autneu.2017.11.001 http://scihub22266oqcxt.onion/10.1016/j.autneu.2017.11.001 29158115!ä!29158115 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Auton+Neurosci 2017 ; 208 (ä): 113-116 Nephropedia Template TP {{tp|p=29158115|t=2017. Trace elements cause oxidative damage in the brain of rats with induced hypotension |pdf=|usr=}}{{29158115}} gab.com Text Trace elements cause oxidative damage in the brain of rats with induced hypotension JO: Auton Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=29158115 #FOAvip Hypertension causes neuronal damage and apoptosis in the brain. Diazoxide is a drug used in the treatment of hypertension however, its effect on 5-hydroxyindole acetic acid (5-HIAA) and dopamine amines in adult animal models remains unclear. The purpose of this study was to determine the effect of oligoelements on 5-HIAA and dopamine in the brain of adult rats treated with diazoxide METHODS: Male Fisher rats (weight 250g) were treated as follows: Group I, NaCl 0.9% (control); group II, tracefusin(R) (1.5mL/rat); group III, diazoxide (20mg/rat) and group IV, tracefusin(R) (1.5mL/rat)+diazoxide (20mg/rat). All doses were intraperitoneally administered on daily basis for four consecutive days. After the last administration, the brain of the animals was obtained and dissected in cortex, hemispheres (striatum) and cerebellum/medulla oblongata to measure the levels of 5-HIAA, dopamine, lipid peroxidation and total ATPase activity through validated methods. RESULTS: Dopamine and 5-HIAA levels decreased significantly in the group that received trace elements and diazoxide in the hemisphere regions, while in cerebellum/medulla oblongata, dopamine levels increased significantly in the groups that received diazoxide alone in. Lipid peroxidation in all brain regions increased significantly in the groups that received trace elements and diazoxide. ATPase dependent of calcium and magnesium decreased in the groups that received diazoxide alone or combined with trace elements in cerebellum/medulla oblongata regions. CONCLUSION: The present results suggest that the use of trace elements and diazoxide alters metabolism of dopamine and 5-HIAA amines. Free radicals may be involved in this effect. Twit Text FOAVip Trace elements cause oxidative damage in the brain of rats with induced hypotension ????Auton Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=29158115 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29158115 #FOAvip English Wikipedia <ref>{{Cite pmid|29158115}}</ref> Trace elements cause oxidative damage in the brain of rats with induced hypotension #MMPMID29158115 Guzman DC; Herrera MO; Brizuela NO; Mejia GB; Olguin HJ; Peraza AV Auton Neurosci 2017[Dec]; 208 (ä): 113-116 PMID29158115show ga Hypertension causes neuronal damage and apoptosis in the brain. Diazoxide is a drug used in the treatment of hypertension however, its effect on 5-hydroxyindole acetic acid (5-HIAA) and dopamine amines in adult animal models remains unclear. The purpose of this study was to determine the effect of oligoelements on 5-HIAA and dopamine in the brain of adult rats treated with diazoxide METHODS: Male Fisher rats (weight 250g) were treated as follows: Group I, NaCl 0.9% (control); group II, tracefusin(R) (1.5mL/rat); group III, diazoxide (20mg/rat) and group IV, tracefusin(R) (1.5mL/rat)+diazoxide (20mg/rat). All doses were intraperitoneally administered on daily basis for four consecutive days. After the last administration, the brain of the animals was obtained and dissected in cortex, hemispheres (striatum) and cerebellum/medulla oblongata to measure the levels of 5-HIAA, dopamine, lipid peroxidation and total ATPase activity through validated methods. RESULTS: Dopamine and 5-HIAA levels decreased significantly in the group that received trace elements and diazoxide in the hemisphere regions, while in cerebellum/medulla oblongata, dopamine levels increased significantly in the groups that received diazoxide alone in. Lipid peroxidation in all brain regions increased significantly in the groups that received trace elements and diazoxide. ATPase dependent of calcium and magnesium decreased in the groups that received diazoxide alone or combined with trace elements in cerebellum/medulla oblongata regions. CONCLUSION: The present results suggest that the use of trace elements and diazoxide alters metabolism of dopamine and 5-HIAA amines. Free radicals may be involved in this effect. |Adenosine Triphosphatases/metabolism[MESH] |Animals[MESH] |Antihypertensive Agents/*pharmacology[MESH] |Brain/drug effects/metabolism/pathology[MESH] |Diazoxide/*pharmacology[MESH] |Disease Models, Animal[MESH] |Dopamine/metabolism[MESH] |Drug Combinations[MESH] |Hydroxyindoleacetic Acid/metabolism[MESH] |Hypertension/*drug therapy/metabolism/pathology[MESH] |Infusions, Parenteral[MESH] |Lipid Peroxidation/drug effects/physiology[MESH] |Male[MESH] |Oxidative Stress/drug effects/*physiology[MESH] |Rats, Inbred F344[MESH] |Starch/*toxicity[MESH] |Talc/*toxicity[MESH] |Tartrates/*toxicity[MESH]Trace elements cause oxidative damage in the brain of rats with induce(epmc).pdf DeepDyve Pubget Overpricing